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Immunosuppression by a Noncytolytic Virus Via T Cell Mediated Immunopathology

Implication for AIDS

  • Chapter
Cell Activation and Apoptosis in HIV Infection

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 374))

Abstract

HIV is basically a non-or poorly cytocidal virus. Therefore, HIV infections in humans represent an apparent perversity in the balance between the host immune system and infectious agent: This noncytopathic virus infects macrophages, antigen presenting cells, helper T cells and other host cells which are then destroyed by the CD8+ T cell immune response. Thus, HIV infects some of the key cells involved in immune reactions and therefore induces the immune system to destroy itself and thereby enables the virus to persist. Accordingly, immunosuppression is not a cause of HIV cytopathogenicity but a consequence of conventional T cell mediated immunopathology that destroys macrophages antigen presenting cells, T helper cells and facilitates infection by trivial intracellular parasites which eventually cause fatal disease. This immunopathological view of AIDS is testable and, if correct, impinges on rationales for AIDS prevention and treatment.

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  1. Institute of Experimental Immunology, University of Zurich, Switzerland

    Rolf M. Zinkernagel

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  1. Laennec Hospital, Paris, France

    Jean-Marie Andrieu  & Wei Lu  & 

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Zinkernagel, R.M. (1995). Immunosuppression by a Noncytolytic Virus Via T Cell Mediated Immunopathology. In: Andrieu, JM., Lu, W. (eds) Cell Activation and Apoptosis in HIV Infection. Advances in Experimental Medicine and Biology, vol 374. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1995-9_14

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  • DOI: https://doi.org/10.1007/978-1-4615-1995-9_14

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