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T Cell Apoptosis as a Consequence of Chronic Activation of the Immune System in HIV Infection

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Book cover Cell Activation and Apoptosis in HIV Infection

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 374))

Abstract

The hallmark of AIDS is the progressive disappearance of CD4+ helper T lymphocytes which, in addition to be the targets of the virus play a major role in the immune system. Although it is likely that the active replication of the virus in lymphoid organs is at least associated with CD4+ T cell depletion, it has become clear that indirect mechanisms have to be considered to explain the extent of immunosuppression. HIV disease is now considered as a multifactorial process and the immunopathogenic mechanisms involved appear to be very complex. In the present review, some of the indirect mechanisms potentially involved in AIDS pathogenesis will be discussed, focusing on the causes and consequences of a persistant and inappropriate activation of the immune system leading to paralysis (anergy) or self destruction (apoptosis) of non-infected patients’ T cells (1-4).

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Authors and Affiliations

  1. Unité d’Oncologie Virale Département SIDA et Rétrovirus, Institut Pasteur, 28 rue du Dr. Roux, Paris Cedex 15, 75724, France

    Marie-Lise Gougeon

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  1. Marie-Lise Gougeon
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  1. Laennec Hospital, Paris, France

    Jean-Marie Andrieu  & Wei Lu  & 

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Gougeon, ML. (1995). T Cell Apoptosis as a Consequence of Chronic Activation of the Immune System in HIV Infection. In: Andrieu, JM., Lu, W. (eds) Cell Activation and Apoptosis in HIV Infection. Advances in Experimental Medicine and Biology, vol 374. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1995-9_11

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  • DOI: https://doi.org/10.1007/978-1-4615-1995-9_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5823-7

  • Online ISBN: 978-1-4615-1995-9

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