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Exercise-Induced Hyperammonemia: Skeletal Muscle Ammonia Metabolism and the Peripheral and Central Effects

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Hepatic Encephalopathy, Hyperammonemia, and Ammonia Toxicity

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 368))

Abstract

The area of ammonia metabolism in skeletal muscle is a vast topic and one that involves both directly and indirectly carbohydrate, fat and protein. To gain an appreciation for hyperammonemia associated with exercise one must also understand the membrane-associated events as well as the clearance mechanisms for ammonia. These cannot be dealt with in detail in this paper and those who wish more information can refer to a variety of recent reviews by this author (1,2) and others (3,4,5,6). This manuscript will address the possible effects that exercise-induced ammonia hyperemia could have on the feelings of fatigue and also will address whether there are local effects within the active muscle. Attention will also be given to the clearance mechanisms that are active in association with exercise states both because they are critical to determining the circulating ammonia concentration and also since they represent aspects of how ammonia affects various tissues. However, before these issues can be addressed the basic aspects of ammonia metabolism in muscle will be reviewed.

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Authors and Affiliations

  1. Human Biology, University of Guelph, Guelph, Ontario, Canada, N1G 2W1

    Terry E. Graham

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  1. Instituto de Investigaciones Citologicas de la F. I. B., Valencia, Spain

    Vicente Felipo  & Santiago Grisolia  & 

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Graham, T.E. (1994). Exercise-Induced Hyperammonemia: Skeletal Muscle Ammonia Metabolism and the Peripheral and Central Effects. In: Felipo, V., Grisolia, S. (eds) Hepatic Encephalopathy, Hyperammonemia, and Ammonia Toxicity. Advances in Experimental Medicine and Biology, vol 368. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1989-8_20

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  • DOI: https://doi.org/10.1007/978-1-4615-1989-8_20

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5820-6

  • Online ISBN: 978-1-4615-1989-8

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