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Fetal Islet Transplantation pp 99–111Cite as

Long-Term Studies with Cultured and Cryopreserved Human Fetal Islets for Islet Transplantation in Hungary

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Abstract

The fetal pancreas has long been viewed as an attractive source of tissue for transplantation by virtue of its relative enrichment in endocrine tissue (or precursors) with respect to exocrine tissue (as compared to the adult organ), and its potentially lesser immunogenicity. However, the result of such transplantation depends on various factors: the quality, quantity and viability of the islets, and the possibility of immunomodulation. Isolated fetal islets basically have a great proliferative capacity in organ cultures, which can provide a large number of islets from one pancreas (36). Unfortunately, this quantity of islets is not sufficient for a complete cure of the diabetic condition in one recipient, but in combination with cryopreserved islet tissue (39), it may provide an opportunity for the treatment of diabetes mellitus and secondary diabetic complications. The fact that fetal islet cells can be maintained in organ cultures also leads to an opportunity for reduction of the immunogenicity of the islets of Langerhans (32, 33). In this article, we study the possibility of long-term cultivation, cryopreservation for the storage of fetal islets, the effect of these procedures in reducing immunogenicity and the role of these conditions in clinical transplantation.

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Author information

Authors and Affiliations

  1. Department of Surgery, Albert Szent-Györgyi Medical University, Szeged, P. O. Box 464, H-6701, Hungary

    Gyula Farkas

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  1. Gyula Farkas
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Editors and Affiliations

  1. Sansum Medical Research Foundation, Santa Barbara, California, USA

    Charles M. Peterson , Lois Jovanovic-Peterson  & Bent Formby ,  & 

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Farkas, G. (1995). Long-Term Studies with Cultured and Cryopreserved Human Fetal Islets for Islet Transplantation in Hungary. In: Peterson, C.M., Jovanovic-Peterson, L., Formby, B. (eds) Fetal Islet Transplantation. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1981-2_9

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  • DOI: https://doi.org/10.1007/978-1-4615-1981-2_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5816-9

  • Online ISBN: 978-1-4615-1981-2

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