Abstract
In 1922, Mrs. Thompson pleaded with doctors in Toronto to save her dying child. Banting and Best (1) had recently shown that a pancreatic extract could lower blood glucose in diabetic dogs, but never before had the hypoglycemic hormone, insulin, been given to a human being. Leonard Thompson thus became the first person to receive insulin. He not only recovered but grew into his third decade, eventually dying from pneumonia.
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References
Bliss, M., 1982, The Discovery of Insulin. Chicago, The University of Chicago Press 28–29.
Diabetes Control and Complications Trial Research Group, 1993, The effect of intensive treatment of diabetes on the development and progression of long term complications in insulin dependent diabetes mellitus, New Eng. J. Med. 329:977–986.
The DCCT Research Group 1987, Effects of Age, Duration and Treatment of Insulin-Dependent Diabetes Mellitus on Residual Beta Cell Function. Observations During Eligibility Testing for Diabetes Control and Complications Trial (DCCT),J. Clin. Endocrinol Metab. 65: 30–36.
Downing, R., 1984, Historical review of pancreatic islet transplantation, World J. Surg. 8: 137–142.
Sutherland DER. 1981, Pancreas and islet transplantaion II Clinical trials, Diabetologia 20: 435–450.
Brown, J., Clark, W.R., Molnar, I.G., and Mullen, Y.S., 1976, Fetal pancreas transplantation for reversal of streptozotocin-induced diabetes in rats, Diabetes 25:56–64.
Brown, J., Molnar, I.G., Clark, W., and Mullen, Y., 1974, Control of experimental diabetes mellitus in rats by transplantation of fetal pancreases, Science 184: 1377–1379.
Sutherland, DER., Goetz, F.C., and Najarian, J.S., 1981,Review of world’s experience with pancreas and islet transplantation and results of intraperitoneal segmental pancreas transplantation from related and cadaver donors at Minnesota,Transplant Proc. 13: 291–297.
Hu,Y.F., 1985, Clinical studies on islet transplantation in 39 patients with insulin-dependent (type I) diabetes mellitus, Wuhan Int. Symp. Organ Transplant. 39–40.
Shumakov,V.I., Bljumkin, V.N., Ignatenko, S.N., 1986, The principal results of pancreatic islet cell culture transplantation in diabetes mellitus patients, Int. Congress Transplant Soc. 11: 40.
Kemp, J. A., Mullen, Y., Weisman,H., Nagata, and M., Matsuo, S., 1978, Reversal of diabetes in rats using fetal pancreases stored at -196C, Transplantation 26: 260–264.
Brown,J., Kemp, J.A., Hurt, S., Nagata, M., Matsuo, S., Taura, Y, and Miyazawa, K., 1980, Cryopreservation of Human Fetal Pancreas, Diabetes 29 Suppl. 1: 170–73.
Peterson, C.M., Jovanovic-Peterson, L., Formby, B., Gondos, B., Monda, L.M., Walker, L., Rashbaum, W.m., and Williams, K., 1989, Human fetal pancreas transplants, J. Diabetes Complications 3: 27–34.
Formby, B., Walker, L., and Peterson, C.M., 1987, Effects of duration of cold storage and gestational age on the insulin secretory capacity of human fetal pancreatic islets, Diabetes Rsrch. 4 13–116.
Formby, B., Walker, L., and Peterson, C.M., 1986, Rapid selection of viable transplantable human fetal pancreatic islets by trypan blue exclusion, Proc. of the Soc. For Exp. Bio. and Med. 182: 245–247.
Usadel, K.H., Schwedes, U., Bastert, G., Steinan, U., Klempa, I., Fassbinder, W., and Schoffling, K., 1980, Transplantation of human fetal pancreas: experience in thymusaplastic mice and rats and in a diabetic patient Diabetes 29: 74–75. 86.
Farkas, G., and Ferenc, J., 1984, Simple and reliable conditions for routine, long-term culturing of fetal human pancreatic tissue fragments,Diabetes 33: 1165–1168.
Mandel, T.E., and Georgiou, H.M., 1983, Insulin secretion by fetal human pancreatic islets of Langerhans in prolonged organ culture, Diabetes 32: 915–920.
Peterson, C.M., Jovanovic, L., Formby, B., Fuhrman, K., Walker,L., Brennan, M., and Rashbaum, W., 1986, Studies of human fetal pancreas. Proceedings of the Second International Conference on the Use of Human Tissues and Organs for Research and Transplant, National Diabetes Research Interchange Phila. PA. 220–222.
Jovanovic-Peterson, L., Williams, K., Brennan, M., Fuhrmann, K., Rashbaum, W., Walker, L., and Peterson, CM., 1988, Studies of Transplantation of human fetal tissue in man. In Peterson, CM., Jovanovic-Peterson, L., Formby, B., (eds) Fetal Islet Transplantation, Springer-Verlag New York. pp: 185–196.
Jovanovic-Peterson, L., Williams, K., Brennan, M., Rashbaum, W., and Peterson, CM., 1989, Studies of human fetal pancreatic allografts in diabetic recipients without immunosuppression, J. Diabetic Complications 3. 1: 27–34.
The DCCT Research Group, 1985, “The informed consent: Is it truly informed?”, Controlled Clin. Trials. 6:223.
Wells, S.A. Jr., Farndon, J.R., and Dale, D.K., 1980, Long term evaluation of patients with primary parathyroid hyperplasia managed by total parathyroidectomy and heterotopic autotransplantation, Ann. Surg. 192:451–458.
Wells, S.A. Jr, Eltes, G.J., and Gunnells, J.C., 1976, Parathyroid autotransplantation in primary parathyroid hyperplasia, N. Eng. J. Med 295: 57–62.
Brennan, M.F., Marx, S.J., and Dappman, J.L., 1981, Results of reoperation for persistent and recurrent hyperthyroidism, Ann. Surgery 194: 671–676.
Pickup, J.C., Keen, H., Parsons, J.A., and Alberti, KGMM, 1978, Continuous subcutaneous insulin infusion: an approach to achieving normoglycemia. Br. Med. J., 1:204–207.
Pavlovskii, M.P., and Boiko, N.I., 1990, Imeni ii Grokova, 145:256–259.
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Jovanovic-Peterson, L., Formby, B., Wollitzer, A.O., Peterson, C.M. (1995). The Use of Human Fetal Islet Tissue for Adjunctive Treatment in Insulin-Dependent Diabetic Patients: The Case for “Partial Success”. In: Peterson, C.M., Jovanovic-Peterson, L., Formby, B. (eds) Fetal Islet Transplantation. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1981-2_8
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DOI: https://doi.org/10.1007/978-1-4615-1981-2_8
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