Abstract
We have been undertaking the studies on experimental islet transplantation since 1978 and clinical islet transplantation with short-term cultured human fetal islet tissue in patients with insulin-dependent (type I) diabetes mellitus since 1981 (1–4). On entrustment of the Ministry of Health, we have sponsored several special courses from 1984 to 1986 to popularize islet transplantation in China. The National Cooperating Group for study of Islet Transplantation was established in 1985. There has been great progress in clinical islet transplantation in China in recent years (5–7). According to the data of the Islet Transplant Registry of the National cooperating Group, as of the end of 1991, there were 939 patients with type I diabetes altogether having received islet grafts in 59 hospitals all over China, 835 of them with integral data. This article will present the influences of pretreatment in vitro on the immunogenecity of human fetal islet and an analysis of the clinical data of 835 diabetics with islet grafts.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Hu Y.F., Zhang H., Zhang H.D., et al: Experimental studies on islet allotransplantation in 114 alloxan-in-duced diabetic rats. Chinese J Organ Transplant 1981; 2:77–81
Hu Y.F., Zhang H., Zhang H.D., et al: Clinical studies on islet transplantation in 20 patients with insulin-dependent diabetes mellitus. Chinese J Intern Med 1983; 22:288–292
Hu Y.F., Zhang H., Zhang H.D., et al: Culture of human pancreas and islet transplantation in 24 patients with type I diabetes mellitus. Chinese Med J (Engl. Ed.) 1985; 98:236–243
Hu Y.F., Zhang H., Zhang H.D., et al: Islet transplantation in 39 patients with insulin-dependent diabetes mellitus. in Advanced Model for the Therapy of Insulin-dependent Diabetes. Ed. Brunetti P. and Waldhausl W.K. Raven Press, New York 1987, pp.309–313
Hu Y.F., Cheng R.L., Shao A.H., et al: The Influence of islet transplantation on metabolic abnormalities and diabetic complications. Horm Metabol Res 1989; 21:198–202
Hu Y.F., Gu Z.F., Zhang H.D. and Ye R.S.: Fetal islet cell transplantation in China. Transplant Proc 1989; 21:2605–2607
Hu Y.F., Gu Z.F., Zhang H.D. and Ye R.S.: Fetal islet transplantation in 755 patients with insulin-dependent diabetes mellitus in China. Diab Nutr.& Metabol 1992; 5(Suppl 1): 199–202
Hu Y.F., Wang Y.F., Ding Y.M., et al: Monolayer culture of human fetal pancreatic islet cells. Chinese J Organ Transplant 1990, 11:158–160
Faustman D, Lacy P.E. and Davie J.M.: Transplantation without immunosuppression. Diabetes 1982; 31(Supp14):11–14
Alejandro R., Shienold F.L., Hajek S.V., et al: Immunocytochemical localization of HLA-DR in human islet of langerhans. Diabetes 1982; 31(Suppl 4): 17–22
Mandel T.E., Hoffman L., Collier S., Carter W.M. and Koulmanda M.: Organ culture of fetal mouse and fetal human pancreatic islet for allografting. Diabetes 1982; 31(Suppl 4):39–47
Rabinovitch A., Alejandro R., Noel J.,Brunschwig J.P and Ryan U.S.: Tissue culture reduces Ia-antigen-bearing cells in rat islets and prolongs islet allografts survival. Diabetes 1982; 3 l(Suppl 4):48–54
Markmann J.K., Tomasxewski J., Posselt A.M., et al: The effect of islet culture in vitro at 24 degree C on graft survival and MHC antigen expression. Transplantation 1990; 49:272–277
Lacy RE., Davie J.M., Finke E.H.: Prolongation of islet allografts survival following in vitro culture (24°C) single injection of ALS. science 1979; 204:312–313
Mark S.C., Garth L.W., Norman M.K.: The effect of cryopreservation on the survival and MHC antigen expression on murine islet grafts. Transplantation 1993; 55:159–163
Eloy R., Doillon C., Inbois P.: Fetal pancreatic transplantation: Review of experimental data. Transplant Proc 1980; 12(Suppl 2): 179–185
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1995 Springer Science+Business Media New York
About this chapter
Cite this chapter
Hu, YF. et al. (1995). Studies on Pretreatment of Human Fetal Islet In Vitro and Clinical Islet Transplantation in China. In: Peterson, C.M., Jovanovic-Peterson, L., Formby, B. (eds) Fetal Islet Transplantation. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1981-2_7
Download citation
DOI: https://doi.org/10.1007/978-1-4615-1981-2_7
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-5816-9
Online ISBN: 978-1-4615-1981-2
eBook Packages: Springer Book Archive