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Expression of Two Non-Allelic Reg Genes in the Developing Human Pancreas: Effects in Vitro of Nicotinamide and Maternal Growth Factors

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Fetal Islet Transplantation

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Abstract

Several characteristics make fetal tissue superior to adult tissue for transplantation (1). Thus, fetal cells can often differentiate in response to environmental signals or according to an intrinsic program. This plasticity means that such cells may migrate, grow and establish functional connections with other cells. Additionally, fetal cells may proliferate more rapidly and more often than mature, fully differentiated cells. They may produce high levels of angiogenic factors, which enhance their ability to grow once they are grafted and may also facilitate regeneration of surrounding host tissues (2). Major histocompatibility antigens (HLA’s) are expressed at lower levels in some fetal tissues than in corresponding adult tissues, which makes the fetal tissue less susceptible to rejection by the recipients immune system. Fetal tissue is more resistant to ischemic damage during in vitro manipulation or after transplantation (3), and therefore can survive at lower oxygen tensions than adult tissue, which probably explains why fetal tissues and cells better survive refrigeration or cryopreservation than those of adults (4).

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Authors and Affiliations

  1. Sansum Medical Research Foundation, Santa Barbara, California, USA

    Bent Formby, Jean Falzone & Sheng Loh

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  1. Bent Formby
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  2. Jean Falzone
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  3. Sheng Loh
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Editor information

Editors and Affiliations

  1. Sansum Medical Research Foundation, Santa Barbara, California, USA

    Charles M. Peterson , Lois Jovanovic-Peterson  & Bent Formby ,  & 

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Formby, B., Falzone, J., Loh, S. (1995). Expression of Two Non-Allelic Reg Genes in the Developing Human Pancreas: Effects in Vitro of Nicotinamide and Maternal Growth Factors. In: Peterson, C.M., Jovanovic-Peterson, L., Formby, B. (eds) Fetal Islet Transplantation. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1981-2_2

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  • DOI: https://doi.org/10.1007/978-1-4615-1981-2_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5816-9

  • Online ISBN: 978-1-4615-1981-2

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