Summary
Several animal models are now available for the study of pregnancy complicated by diabetes mellitus and thus studies of islet transplantation in these pregnant animals can also be performed. Animals may be made hyperglycemic by the use of alloxan or streptozotocin. Infusion protocols of glucose and/or insulin have been described in several species including rats and monkeys. Recently described genetic models include the BB Wistar rat, the NOD mouse, the C57/KsJdb+/+m mouse, and the Chinese hamster with spontaneous diabetes (CHAD). The NOD mouse is particularly attractive for studies of transplantation since it has several features in common to the human autoimmune counterpart. Studies of subcutaneous fetal islet transplantation in this model as well as in humans during gestation suggest improved graft survival and insulin secretory capacity. The nature of the factors during pregnancy that lead to enhanced tissue vascularization, improved tissue growth and secretory capacity, and decreased immunological response in pregnant recipients are noteworthy and warrant further study.
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References
Neufeld, N.D., 1986, Gestational diabetes and congenital anomalies. IN: Jovanovic, L., Peterson, C.M., Fuhrmann, K., eds. Diabetes and Pregnancy New York, Prager 37–50.
Baird, J.D., Aerts, L., 1987, Research priorities in diabetic pregnancy today: the role of animal models, Biology of the Neonate 51:119–127.
Freinkel, N., 1980, Of pregnancy and progeny, Diabetes 29:1023–1035.
Eriksson, U.J., 1988, Importance of genetic predisposition and maternal environment for the occurrence of congenital malformations in offspring of diabetic rats, Teratology 37:365–374.
Eriksson, U.J., Karlsson, M.G., Styrud, J., 1987, Mechanisms of congenital malformations in diabetic pregnancy, Biology of the Neonate 51:113–118.
Eriksson, U.J., Borg, L.A., Forsberg, H., Styrud, J., 1991, Diabetic embryopathy. Studies with animal and in vitro models, Diabetes 40 Suppl 2:94–98.
Sadler, T.W., Horton, W.E., Hunter, E.S., 1986. Mechanisms of diabetes-induced congenital malformations in infants of diabetic mothers as studied in mammalian embryo culture. In: Jovanovic, L., Peterson, C.M., Fuhrmann, K. eds. Diabetes and Pregnancy. New York: Prager, 51–71.
Freinkel, N., 1988. Diabetic embryopathy and fuel-mediated organ teratogenesis: lessons from animal models, Hormone and Metabolic Research . 20:463–475.
Dickinson, J.E., Meyer, B.A., Chmielowiec, S., and Palmer, S.M., 1991, Streptozocin-induced diabetes mellitus in the pregnant ewe, American Journal of Obstetrics and Gynecology 165:1673–1677.
Lips, J.P., Jongsma, H.W., and Eskes, T.K., 1988, Alloxan-induced diabetes mellitus in pregnant sheep and chronic fetal catheterization, Laboratory Animals 22:16–22.
Thompson, S.C., and Mandel, T.E., 1990, Fetal pig pancreas. Preparation and assessment of tissue for transplantation, and its in vivo development and function in athymic (nude) mice, Transplantation, 49:571–581.
Levy, J., Gavin, J.R. 3rd, Scott, M.J., and Avioli, L.V., 1987, Mineral homeostasis in neonates of streptozotocin-induced noninsulin-dependent diabetic rats and in their mothers during pregnancy and lactation. Bone 8:1–6.
Johansson, B., Meyerson, B., and Eriksson, U.J., 1991, Behavioral effects of an intrauterine or neonatal diabetic environment in the rat, Biology of the Neonate 59:226–235.
Thomas, C.R., Eriksson, G.L., and Eriksson, U.J.,1990, Effects of maternal diabetes on placental transfer of glucose in rats, Diabetes 39:276–282.
Neufeld, N.D., Corbo, L., Stoddard, A., Klein, A.H. and Tadokoro, N., 1989, Oxygen consumption and guanosine diphosphate binding by fetal brown adipose tissue in diabetic pregnancy, Metabolism: Clinical and Experimental, 38:831–836.
Canavan, J.P., Holt, J., and Goldspink, D.F., 1991, Growth of the rat foetal liver in gestational diabetes. Comparative Biochemistry and Physiology, a: Comparative Physiology, 99:473–476.
McDowell, E.M., Coleman, W.P., De Santi, A.M., Newkirk, C., and Strum, J.M., 1990, Development of the conducting airway epithelium in fetal Syrian golden hamsters during normal and diabetic pregnancies, Anatomical Record, 227:111–123.
Gauguier, D., Bihoreau, M.T., Ktorza, A., Berthault, M.F., and Picon, L., 1990, Inheritance of diabetes mellitus as consequence of gestational hyperglycemia in rats. Diabetes, 39:734–739.
Van Assche, F.A., Aerts, L., and Verhaeghe, J., 1988, Fetal consequences of maternal diabetes. IN: Weiss, P. A.M., Coustan, D.R., Eds. Gestational Diabetes. Vienna: Springer-Verlag, 153–160.
Aerts, L., Sodoyez-Goffaux, F., Sodoyez, J.C., Malaisse W.J., and Van Assche, F.A., 1988, The diabetic intrauterine milieu has a long-lasting effect on insulin secretion by B cells and on insulin uptake by target tissues. Am. J. Obstet. Gynecol. 159:1287–1292.
Susa, J.B., Boylan, J.M., Sehgal, P., and Schwartz, R., 1990, Impaired insulin secretion in the neonatal rhesus monkey after chronic hyperinsulinemia in utero. Proc. of the Society for Exper.Biol.and Med., 194:209–15.
Susa, J.B., McCormick, K.L., Widness, J.A., Singer, D.B., Oh, W., Adamsons, R., and Schwartz, R., 1979, Chronic hyperinsulinemia in the fetal rhesus monkey. Diabetes 18: 1058–1063.
Susa, J.B., Gruppuso, P.A., Widness, J.A., Domenech, M., Sehgal, P., and Schwartz R.,1984. Chronic hyperinsulinemia in the fetal rhesus monkey: Effects of physiologic hyperinsulinemia on fetal substrates, hormones, and hepatic enzymes. Am .J. Obstet. Gynecol. 150:415–420.
Kaufmann, R.C., Khosho, F.K., Verhulst, S.J., and Amankwah, K.S. 1991 .Effect of pregnancy on glucose metabolism in glucose intolerant ’BB’ Wistar rats. American Journal of Perinatology, 8:11–14.
Brownscheidle, C.M., 1986, The BB rat: Type I diabetes and congenital malformations. IN: Jovanovic, L., Peterson, C.M., Fuhrmann, K. eds. Diabetes and Pregnancy. New York: Prager, 15–36.
Brownscheidle, C.M., Wootten, B., Mathieu, M.H., Davis, D.L., and Hofmann, I.A. 1983, The effects of maternal diabetes on fetal maturation and neonatal health. Metabolism 32 (Suppl 1): 148–155.
Formby, B., Schmid-Formby, F., Jovanovic, L., and Peterson, CM. 1987, The offspring of the female diabetic “nonobese diabetic” (NOD) mouse are large for gestational age and have elevated pancreatic insulin content: a new animal model of human diabetic pregnancy. Proc. of the Society for Exper. Biol. and Med. 184:291–4.
Todd, J.A., Altman, T.J., Cornall, R.J., Ghosh, S., Hall, J.R.S., Heame, CM., Knight, A.M., Love, J.M., McAleer, M.A., Prinws, J-B., Rodrigues, N., Lathrop, M., Pressey, A., DeLarato, N.Y.H., Peterson, L.B., and Wicker LS. 1991, Genetic analysis of autoimmune type 1 diabetes mellitus in mice. Nature 351:542–47.
Prochazka, M., Serreze, D.V, Frankel, W.N., Leiter, E.H. 1992, NOR/Lt mice: MHC matched diabetes- resistant control strain for NOD mice. Diabetes 41:98–106.
Siddiqi, T.A., Miodovnik, M., Mimouni, F., Clark, E.A., Khoury, J.C., and Tsang, R.C 1989, Biphasic intrauterine growth in insulin-dependent diabetic pregnancies. J. of the Am. Coll. of Nutri. 8:225–234.
Bevier, W.C., Jovanovic-Peterson, L., Formby, B., and Peterson, CM., 1994, Maternal hyperglycemia is not the only cause of macrosomia: Lessons learned from the non-obese diabetic mouse. Am. J. Perinatol. 11:51–56.
Schroeder, R., Devaskar, U., Holtzclaw, L., deMello, D., and Devaskar, S., 1990 Maternal diabetes regulates placental glucose transporter (GT) gene expression. Clinical Resrch. 38:804A.
Hrubec, Z., Robinette, CD., 1984, The study of human twins in medical research. N. Engl. J. Med. 310:435.
Kramer, M.S., 1987, Determinants of low birth weight: methodological assessment and meta-analysis. Bull. W.H.O. 65:683–737.
Kaufmann, R.C., Amankwah, K.S., Colliver, J.A., and Arbuthnot, J., 1987, Diabetic pregnancy. The effect of genetic susceptibility for diabetes on fetal weight. Am. J. of Perinatol. 4:72–74.
Sasaki, K., 1987, Studies of fetal lung maturity of maternal spontaneous diabetes in the Chinese hamster. Nippon Sanka Fujinka Gakkai Zasshi. Acta Obstetrica et Gynaecologica Japonica, 39:1607–14 .
Mosman, T.R., and Coffman, R.L., 1989, Thl and Th2 cells: Different pattern of cytokine secretion leads to different functional properties. Ann. Rev. Immunol. 7:145.
Mosman, T.R., and Coffman, R.L., 1987, Two types of mouse helper T-cell clone. Immunol. Today 8:223
Dudley, D.J., Chen, C-L., Mitchell, M.D., Dajres, R.A., Araneo B.A., 1993, Adaptive immune responses during murine pregnancy: Pregnancy-induced regulation of lymphokine production by activated T lymphocytes. Am. J. Obstet. Gynecol. 168:1155.
Clark, D.A., Falbo, M., Rowley, R.B., Banwatt, D., and Stedronska-Clark, J., 1988, Active suppression of host-vs-graft reaction in pregnant mice. IX. Soluble suppressor activity obtained from allopregnant mouse decidua that blocks the cytolytic effector response to IL-2 is related to transforming growth factor-b. J Immunol. 141:3833.
Fiorentino, D.F., Bond, M.W., and Mosman, T.R., 1989, Two types of mouse T helper cell. IV. Th2 clones secret a factor that inhibits cytokine production by Thl clones. J. Exp. Med. 170:2081.
Lin, H., Mosmann, T.R., Guilbert, L., Tuntipapitat, S., and Wegmann, T.G.,1993, et al: Synthesis of T helper 2-type cytokines at the maternal-fetal interface. J. Immunol. 151:4562.
Chaouat, G.E., Menu, E., Clark, D.A., Dy, M., Minkowsk, M, and Wegmann, T.G., 1990, Control of fetal survival in CBAxDBA/2 mice by lymphokine therapy. J. Reprod. Fertil. 89:447.
Drake, B.L., and Head, J.R., 1989, Murine trophoblast can be killed by lymphokine-activated killer cells. J. Immunol. 143:9.
Robertson, S.A., Mayrhofer, G., and Seamark, R.F. 1992, Uterine epithelial cells synthesize granulocytezacrophage-stimulating factor (GM-CSF) and interleukin-6 (IL-6) in pregnant and non-pregnant mice. Biol. Reprod. 46:1069.
Holland, D., Bretscher, P, and Russell, A.S., 1984, Immunologic and inflammatory responses during pregnancy. Clin. Lab. Immunol. 14:177.
Boumpas, D., 1993, Glucocortoid therapy for immune-mediated diseases: Basic and clinical correlates. Ann. Intern. Med. 119:198.
Luft, B.J., and Remington, J.S., 1984. Effect of pregnancy on augmentation of natural killer activity by corynebacterium parvum and toxoplasma gondii. J. Immunol. 132:2375.
Madden, J.D., Siiteri, P.K., and MacDonald, P.C., 1976, The pattern and rates of metabolism of maternal plasma dehydroepiandrosterone sulfate in human pregnancy. Am. J. Obstet. Gynecol. 125:915.
Asibey-Berko, E., Thomas, J., and Stricker, R.C., 1986, 3b-Hydroxy-steroid dehydrogenase in human placental microsomes and mitochondria: co-solubilization of androstene and pregnene activities. Steroids 47:351.
Szekeres-Bartho, J., Varga, P., Kinsky, R., and Chaou, A.T., 1990, Progesterone mediated immunosuppression and the maintenance of pregnancy. Rsrch. in Immunology. 175–181.
Wegmann, T.G., Lin, H., Guilbert, L., and Mesnamm, T.R., 1993, Bidirectional cytokine interactions in the maternal-fetal relationship: Is successful pregnancy a Th2 phenomen? Immunol. Today. 14:353.
Chen, H.L., Yang, Y.P., HU, X.L., Velavarthi, K.K., Fishbach, and Hunt, J.S., 1991, Tumor necrosis factor alpha mRNA and protein are present in human placental and uterine cells at early and late stages of gestation. Am. J. Pathol. 139:327.
Austgulen, R., Liabakk, N.B., Brockhaus, M., and Espevik, T., 1992, Soluble TNF receptors in amnionic fluid and urine from pregnant women. J. Reprod. Immunol. 22:105.
Austgulen, R., Espevik, T., and Mescei, R., 1992, Expression of receptors for tumor necrosis factor in human placenta at term. Acta. Obstet. Gynecol. Scand. 71:417.
Austgulen, R., Johnsen, H., Kjollesdal, A.M., Liabakk, N.P., and Espevik, T., 1993, Soluble receptors for tumor necrosis factor: occurrence in association with normal delivery at term. Obstet. Gynecol. 82:343.
Opsjin, S.L., Wathen, N.C., Tingulstad, S., Wiedswang, G., Sundan, A., Waage, A., and Austgulen, R., 1993, Tumor necrosis factor, interleukin-1, and interleukin-6 in normal human pregnancy. Am. J. Obstet. Gynecol. 169:397.
Wahbeh, C.J., Hill, G.B., Eden, R.D., and Gall, S.A., 1984, Intra-amniotic bacterial colonization in premature labor. Am. J. Obstet. and Gynecol. 148:739.
Chamberlain, G.,1984, Epidermiology and etiology of the preterm baby. Clin. Obstet. Gynecol. 11:297.
Casey, M.L., Cox, S., Beutler, B., Ward, R.A., Mand MacDonald, PL. 1990, Cytokines and infection induced preterm labor. Fertility and Develop. 2:499.
Novy, M.J., and Liggens, G.C. 1980, Role of prostaglandins, prostacyclin, and thomboxanes in the physiological control of the uterus in parturition. Sem. Perinatol. 4:45.
Bry, K., and Lappalainen, U., 1994, Interleukin-4 and transforming growth factor-bl modulate the production of interleukin-1 receptor antagonist and prostaglandin E2 by ducidual cells. Am. J. Obstet. Gynecol. 170:1194.
Da Silva, J.A., and Spector, T.D.,1992, The role of pregnancy in the course and aetiology of rheumatoid arthritis. Clin. Rheumatol. 11:189.
Oka, M., and Vainio, U., 1966, Effect of pregnancy on the prognosis and serology of rheumatoid arthritis. Acta. Rheum. Scand. 12:47.
Ostensen, M., Aune, B., Husby, G., 1983, Effect of pregnancy and hormonal changes on the activity of rheumatoid arthritis. Scand. J. Rheumatol. 12:69.
Nelson, J.L., Hughes, K.A., Smith, A.G., Nisperoc, B.B., Branchand, A.M., and Hansen, J.A., 1993, Meternal-fetal disparity in HLA class II alloantigens and the pregnancy-induced amelioration of rheumatoid arthritis. N. Engl. J. Med. 329:466.
Salgame, P., Convit, J., and Bloom, B.R., 1991, Immunological suppression by human CD8 T cells is receptor dependent and HLA-DQ restricted. Proc. Natl. Acad. Sci. USA 88:2598.
Rudensky, A.Y., Preston-Hurlburt, P., Hong, S.C., Barlow, A., andjareway, C.A., 1991, Sequence analysis of peptides bound to MHC class II molecules. Nature 353:622.
Duquette, P., Girard, M., 1993, Hormonal factors in susceptibility to multiple sclerosis. Opinion Neurol. Neurosurg. 6:195.
Birk, K., and Rudick, R., 1986, Pregnancy and multiple sclerosis. Acta. Neurol. 43:719.
Korn-Lubetzki, I., Kahana, E., and Cooler, G., 1984, Activity of multiple sclerosis during pregnancy and puerperium. Ann. Neurol. 16:229.
Mamula, M.J., Fatenejad, S., and Craft, J., 1994, B cells process and present lupus autoantigens that initiate autoimmune T cell responses. J. Immunol. 152:1453.
Mao, C., Osman, G.E., Adams, S., Datta, S.K., 1994, T cell receptor alpha-chain repertoire of pathogenic autoantibody-inducing T cells in lupus mice. J. Immunol. 152(3): 1462–1470.
Al-Janadi, M, and Raziuddin, S., 1993, B cell hyperactivity is a function of T cell derived cytokines in systemic lupus erythematosus. J. Rheumatol. 20:1885.
Varner, M.W., 1991, Autoimmune disorders and pregnancy. Sem. Perinatol. 15:238.
Grubeck-Loebenstein, B., Turner, M., Pirich, K., Kassal, H., Londei, M., Waldhausl, W., 1990, CD4+ T-cell clones from autoimmune thyroid tissue cannot be classified according to their lymphokine production. Scand. J. Immunol. 32(5):433–440.
Protti, M.P., Manfredi, A.A., and Horton, R.M., 1993, Myastenia gravis: recognition of a human autoantigen at the molecular level. Immunol Today 14:363.
Yi, Q., Ahlberg, R., Pirskanen, R. Lefvert, A.K., 1994, Acetylcholine receptor-reactive T cells in myasthenia gravis: evidence for the involvement of different subpopulations of T helper cells. J. Neuroimmunol. 50(2): 177–186.
Mitchell, P.J., and Bebbington, M., 1992, Myasthenia Gravis in pregnancy. Obstet. Gynecol. 80:178.
Chen, H-M., Jovanovic-Peterson, L., Desai, T.A., and Peterson, C.M., 1994, Leasons learned from the NOD mouse: Studies of subcutaneous neonatal/fetal islet transplantation. Submitted.
Brown, J., Clark, W.R., Molnar, I.G., and Mullen, Y.S., 1976. Fetal pancreas transplantation for reversal of streprozotocin-induced diabetes in rats. Diabetes, 25:56–64.
Brown, J., Molnar, I.G., Clark, W.R., and Mullen, Y.S., 1974, Control of experimental diabetes mellitus in rats by transplantation of fetal pancreas. Science 184:1377–1379.
Aerts, L., and Assche, F.A., 1992, Islet transplantation in diabetic pregnant rats normalizes glucose hormeostasis in their offsprings. J.of Develop. Phys.iol, 17(6):283–287.
Ryan, E.A., Tobin, B.W., Tang, J. and Finegood, D.T., 1993, A new model for the study of mild diabetes during pregnancy. Syngeneic islet-transplanted STZ-induced diabetic rats. Diabetes, 42(2):316–323.
Takayama, Y., Ichikawa, T., and Maki, T., 1993, Effect of STZ administration on islet isograft and allograft survival in NOD mice. Diabetes, 42:324–329.
Kai, N., Motojima, K., Shiogama, T., Terada, M., Tamaki, S., Tsunoda, T., and Kanematsu, T., 1992, A study on the timing of immunologic priming in autoimmune insulitis in NOD mice. Transplan. Proc., 24:1040–1041.
Purcell, L.J., Mottram, P.L., and Mandel, T.E., 1992, The transplantation of segmental pancreas isografts in onoobese diabetic mice. Transplant. Proc. 245:2299.
Purcell, L.J., Mottram, P.L., Green, M.K., and Mandel, T.E., 1992, Transplantation of the segmental pancreas in STZ-treated diabetic mice. Transplant. Proc. 24;236–237.
Nomura, Y., Mullen, Y., and Stein E., 1993, Syngeneic islets transplanted into the thymus of newborn mice prevent diabetes and reduce insulitis in the NOD mouse. Transplant. Proc. 25:963–964.
Weber, C, Krekun, S., Koschitzky, T., Zabinski, S., D’Agati, V., Hardy, M., and Reemtsma, K., 1991, Prolonged functional survival of rat-to-NOD mouse islet xenografts by ultraviolet-B (UV-B) irradiation plus microencapsulation of donor islets. Transplant. Proc. 23:764–766.
Wang, Y, Pontesilli, O., Gill, R.G., La Rosa, F.G., and Lafferty, K.J., 1991, The role of CD4+ and CD8+ T cells in the destruction of islet grafts by spontaneously diabetic mice. Proc. National Acad. of Sci. of the USA, 88(2):527–531.
Jovanovic, L., Druzin, M., and Peterson, C.M., 1981, The effect of euglycemia on the outcome of pregnancy in insulin-dependent diabetics as compared to normal controls. Am. J. Med. 71:921–927.
Csapo, A.L., \Pulkkinen, M.O., and Wiest, W.G., 1973, Effects of luteectomy and progesterone replacement in early pregnant patients. Am. J. Obstet. Gynecol. 115:759.
Jaffe, R.B., 1978, The Endocrinology of Pregnancy. In: Yen, S.S.C., Jaffee, R.B., eds. Reproductive Endocrinology: Physiology, Pathophysiology, and Clinical Management. Philadelphia: WB Saunders, 521–536.
Jovanovic, L., Dawood, M.Y, Landesman, R., and Saxena, B.B., 1978, Hormonal profile as a prognostic index of early threatened abortion. Am. J. Obstet. Gynecol. 130:274–276.
Hiriis-Nielsen, J., Nielsen, V., Molsted-Pedersen, L., and Deckert, T., 1986, Effects of pregnancy hormones on pancreatic islets in organ culture. Acta-Endocrinol. (Copenh);lll:336–341.
Kalkhoff, R.K., Jacobson, M., and Lemper, D. 1970, Progesterone, pregnancy and the augmented plasma insulin response. J. Clin. Endocrinol. Metab., 31:24.
Scarpellini, F., Scarpellini, L., Dino, N., and Benvenuto P., 1993, Progesterone immunosuppressive levels and luteal steroid profiles in the cycles induced with clomiphene citrate. Clin, and Exper. Obstet. and Gynecol, 20:182–188.
Kalo-Klein, A., and Witkin, S.S., 1991, Regulation of the immune response to Candida albicans by monocytes and progesterone. Am. J. Obstet.and Gynecol., 164:1351–1354.
Barberia, Jr., Whu-Fadil, S., Kletzky, O.A., Nakamura, R.M. and Mishell, D.R., 1975, Serum prolactin patterns in early human gestation. Am. J. Obstet. Gynecol, 121:1107.
Ho Yuen, B., Cannon, W., Lewis, J., Sy, L., and Woolley, S., 1980, A possible role for prolactin in the control of human chorionic gonadotropin and estrogen secretion by the fetoplacental unit. Am. J. Obstet. Gynecol, 136:286.
Michaels, R.L., Sorenson, R.L., Parsons, J.A., and Sheridan, J.D., 1987, Prolactin enhances cell-to-cell communication among beta-cells in pancreatic islets. Diabetes, 36:1098–1103.
Reber, P.M., 1993., Prolactin and immunomodulation. Am. J. of Med., 95(6):637–644.
Josimovich, J.B. 1971, Placental lactogenic hormone. In: Endocrinology of Pregnancy, New York: Harper & Row, 184–196.
Josmovich, J.B., and MacLaren, J.A., 1962, Presence in the human placenta and term serum of a highly lactogenic substance immunologically related to pituitary growth hormone. Endocrinology, 71:209.
Spellacy, W.N., Buhi, W.C., Schram, J.C., Birk, S.A., and McCreary, S.A., 1971, Control of human chorionic somatomammotropin levels during pregnancy. Obstet. Gynecol, 37:567.
Kim, Y.J., and Felig, P. 1971, Plasma chorionic somatomammotropin levels during starvation in midpregnancy.J. Clin. Endocrin. Metab., 32:864.
Gaspard, V.J., Sandront, H.M., Luyckx, A.S., and Lefebvre, P.J. 1975, The control of human placental lactogen (HPL) secretion and its interrelation with glucose and lipid metabolism in late pregnancy. In: Camerini-Davalos, R.H., Coles, H.S., eds. Early Diabetes in Early Life, New York:Academic Press 273–278.
Medina, K.L., and Kincade, P.W., 1994, Pregnancy-related steroids are potential negative relators of B lymphopoiasis. Proc. Natl. Acad. Sci. 91:5382–5386.
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Peterson, C.M. et al. (1995). Fetal Islet Transplantation and Pregnancy. In: Peterson, C.M., Jovanovic-Peterson, L., Formby, B. (eds) Fetal Islet Transplantation. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1981-2_10
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