Abstract
Members of the erbB family of growth factor tyrosine kinase receptors have been implicated in breast cancer (Walker and Varley, 1993). The epidermal growth factor receptor (EGFR) or c-erbB is overexpressed in around 35% of breast tumours (Sainsbury et al., 1985) but there is no evidence that this affects mammary epithelial development in vivo. We have expressed a constitutively activated form of the EGFR, the v-erbB oncogene from the chicken erythroblastosis retrovirus, in mammary epithelium using our novel tissue reconstitution system (Edwards et al., 1988). In previous experiments using this system, the introduction of activated rat neu/c-erbB2 into the mammary gland produced abnormalities in epithelial growth resembling those seen in human breast cancer (Bradbury et al., 1993).
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References
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© 1995 Springer Science+Business Media New York
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Abram, C.L., Bradbury, J.M., Page, M.J., Edwards, P.A.W. (1995). V-erbB Induces Abnormal Patterns of Growth in Mammary Epithelium. In: Wilde, C.J., Peaker, M., Knight, C.H. (eds) Intercellular Signalling in the Mammary Gland. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1973-7_7
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DOI: https://doi.org/10.1007/978-1-4615-1973-7_7
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