Endocrine Effect of IGF-I on Mammary Growth in Prepubertal Heifers

  • Stig Purup
  • Yael Sandowski
  • Kris Sejrsen


Pubertal mammary growth in heifers is stimulated by exogenous GH (Sejrsen et al., 1986; Purup et al., 1993). The mechanism of action of GH on the mammary gland, however, is unclear, but evidence favours an indirect action via IGF-I. IGF-I is produced mainly in the liver, but also locally in other tissues, including the mammary gland. Therefore the in vivo effect of GH may be mediated by systemic as well as locally produced IGF-I. To elucidate this question we investigated the effect of sera from GH-treated and control (placebo-treated) heifers on mammary cell proliferation in vitro.


Growth Medium Mammary Gland Mammary Epithelial Cell Mammary Tissue Endocrine Effect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. McFadden, T.B., Akers, R.M. and Beal,W.E., 1989, Influence of breed and hormones on production of milk proteins bymammary explants from prepubertal heifers, J. Dairy Sci.72:1754.PubMedCrossRefGoogle Scholar
  2. Purup, S., Sejrsen, K., Foldager, J. andAkers, R.M., 1993, Effect of exogenous bovine growth hormone and ovariectomy onprepubertal mammary growth, serum hormones and acute in vitroproliferativeresponse of mammary explants from Holstein heifers, J. Endocrinol.139:19.PubMedCrossRefGoogle Scholar
  3. Sejrsen, K., Foldager, J., Sørensen, M.T., Akers,R.M. and Bauman, D.E., 1986, Effect of exogenous bovine somatotropin onpubertal mammary development in heifers, J. Dairy Sci. 69:1321.CrossRefGoogle Scholar
  4. Shamay,A., Cohen, N., Niwa, M. and Gertler, A., 1988, Effect of insulin-like growthfactor I on deoxyribonucleic acid synthesisand galactopoiesis in bovine undifferentiated and lactating mammary tissuein vitro, Endocrinology123:804.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Stig Purup
    • 1
  • Yael Sandowski
    • 2
  • Kris Sejrsen
    • 1
  1. 1.Department of Research in Cattle and SheepNational Institute of Animal Science, Research Centre FoulumTjeleDenmark
  2. 2.Department of Biochemistry, Food Science and NutritionThe Hebrew University of JerusalemRehovotIsrael

Personalised recommendations