Skip to main content

Evidence of Growth Factor Production by Sheep Myoepithelial and Alveolar Epithelial Cells: Potential for Autocrine/Paracrine Interactions

  • Chapter
Intercellular Signalling in the Mammary Gland
  • 156 Accesses

Abstract

The major endocrine factors which control the development of the mammary gland in pregnancy are well known. However, exposure of ruminant mammary epithelial cells in vitro to oestradiol, progesterone, glucocorticoids, prolactin, growth hormone and placental lactogen has little or no effect on DNA synthesis (Winder et al.,1989). Hormone action in vivo may be indirect through stimulation of or interaction with growth factors, some of which may be produced locally and act in an autocrine or paracrine manner.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 16.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Forsyth, I.A., and Villa, M., 1994, Stimulation of DNA synthesis in myoepithelial cells derived from sheep mammary gland by insulin-like growth factor-I (IGF-I) and transforming growth factor-a (TGF-α), J. Endocr. 140 supplement:201.

    Google Scholar 

  • Li, J., Saunders, J.C., Gilmour, R.S., Silver, M., Fowden, A.L., 1992, Insulin-like growth factor-II messenger ribonucleic acid expression in fetal tissues of the sheep during late gestation: effects of cortisol, Endocrinology 132:2083.

    Article  Google Scholar 

  • McGrath, M.F., Collier, R.J., Clemmons, D.R., Busby, W.H., Sweeny, CA., and Krivi, G.G. ,1991, The direct in vitro effect of insulin-like growth factors (IGFs) on normal bovine mammary cell proliferation and production of IGF binding proteins, Endocrinology 129:671.

    Article  PubMed  CAS  Google Scholar 

  • Winder, S.J., Turvey, A., and Forsyth, I.A., 1989, Stimulation of DNA synthesis in cultures of ovine mammary epithelial cells by insulin and insulin-like growth factors, J. Endocr. 123:319.

    Article  PubMed  CAS  Google Scholar 

  • Winder, S.J., Turvey, A., and Forsyth, I.A., 1992, Characteristics of ruminant mammary epithelial cells grown in primary culture in serum-free medium, J. Dairy Res. 59:491.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1995 Springer Science+Business Media New York

About this chapter

Cite this chapter

Forsyth, I.A., Taylor, J.A., Villa, M., Gilmour, R.S. (1995). Evidence of Growth Factor Production by Sheep Myoepithelial and Alveolar Epithelial Cells: Potential for Autocrine/Paracrine Interactions. In: Wilde, C.J., Peaker, M., Knight, C.H. (eds) Intercellular Signalling in the Mammary Gland. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1973-7_15

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-1973-7_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5812-1

  • Online ISBN: 978-1-4615-1973-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics