Factors Affecting Spontaneous Dendritic Cell-Lymphocyte Clustering in Skin Afferent Lymph
Dendritic cells (DC) are essential accessory cells for the growth of T lymphocytes and there are evidences that DC start to migrate to regional lymph nodes after contact with antigen. Skin afferent lymph freshly drawn from lymphatics contains DC and lymphocytes (LY), and 3–6% of DC form clusters with LY 1. Direct contact between these cells seems to be an integral part of their interaction in vivo. Clustering is the first phase of antigen presentation to LY and modulation of lymph cell cooperation may prove useful in mitigating skin immune response. In this study we demonstrate factors affecting the “spontaneous” binding of DC with autologous LY in their own environment, that is the lymph.
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