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Factors Affecting Spontaneous Dendritic Cell-Lymphocyte Clustering in Skin Afferent Lymph

  • Hanna Galkowska
  • Urszula Wojewodzka
  • Waldemar L. Olszewski
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 378)

Abstract

Dendritic cells (DC) are essential accessory cells for the growth of T lymphocytes and there are evidences that DC start to migrate to regional lymph nodes after contact with antigen. Skin afferent lymph freshly drawn from lymphatics contains DC and lymphocytes (LY), and 3–6% of DC form clusters with LY 1. Direct contact between these cells seems to be an integral part of their interaction in vivo. Clustering is the first phase of antigen presentation to LY and modulation of lymph cell cooperation may prove useful in mitigating skin immune response. In this study we demonstrate factors affecting the “spontaneous” binding of DC with autologous LY in their own environment, that is the lymph.

Keywords

Lymph Cell Spontaneous Cell Afferent Lymph Blood Dendritic Cell Cell Cooperation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Hanna Galkowska
    • 1
  • Urszula Wojewodzka
    • 1
  • Waldemar L. Olszewski
    • 1
  1. 1.Department of Surgical Research and Transplantation Medical Research CenterPolish Academy of SciencesWarsawPoland

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