IL-10 Inhibits the Primary Allogeneic T Cell Response to Human Peripheral Blood Dendritic Cells

  • Christel Buelens
  • Fabienne Willems
  • Géraldine Pierard
  • Anne Delvaux
  • Thierry Velu
  • Michel Goldman
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 378)

Abstract

Most of the immunosuppressive properties of IL-10 are related to its action on antigen presenting cells (APC). Until now, several mechanisms have been described by which IL-10 inhibits the ability of monocytes/macrophages to induce T cell activation. Indeed, IL-10 down-regulates their expression of MHC class II molecules1 as well as of ICAM-1 and B7-1 accessory molecules2,3. Moreover, the inhibition by IL-10 of IL-12 and IL-1 synthesis by monocytes was shown to be responsible for the inhibition of IFN-y production by peripheral blood mononuclear cells (PBMC)4. As far as the effects of IL-10 on dendritic cells are concerned, IL-10 was shown to inhibit the ability of mouse splenic dendritic cells to induce interferon (IFN)-y production by antigen-specific TH1 clones or alloreactive splenic T cells5. In addition, human epidermal Langerhans cells preincubated with IL-10 were found to be deficient in the triggering of a mixed lymphocyte reaction6. As a first approach to study the effects of IL-10 on human peripheral blood dendritic cells (PBDC), we analyzed the influence of IL-10 on a primary allogeneic T cell response induced by those cells.

Keywords

Interferon Gentamicin Thymidine Acac 

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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Christel Buelens
    • 1
  • Fabienne Willems
    • 1
  • Géraldine Pierard
    • 1
  • Anne Delvaux
    • 2
  • Thierry Velu
    • 2
  • Michel Goldman
    • 1
  1. 1.Department of Immunology, Erasmus HospitalFree University of BrusselsBrusselsBelgium
  2. 2.Medical Genetics-IRIBHN, Erasmus HospitalFree University of BrusselsBrusselsBelgium

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