Morpho-Functional Changes of Follicular Dendritic Cells (FDC) and Lymph Node Structure in Simian Immunodeficiency Virus (SIV) Infection
The onset of acquired immunodeficiency syndrome (AIDS) has been reported to coincide with destruction the network of follicular dendritic cells (FDC) in germinal centers of lymph nodes (LNs)1. These observations have led to the theory in which one of underlying mechanisms of HIV pathogenesis may be loss of FDC in LNs2. This process can be investigated in rhesus macaque infected with simian immunodeficiency virus (SIV), developing an immunodeficient disease closely resembling AIDS3. Although the specific role of FDC has been recognized in both HIV- and SIV-induced diseases1,4, up to now little is known about morpho-functional changes of these cells during follicular hyperplasia and follicular involution in LNs. Investigating LNs of monkeys infected with SIV we found that morpho-functional peculiarities of FDC were closely related to virus distribution, local cytokine production and structure of lymphoid tissue.
KeywordsGerminal Center Simian Immunodeficiency Virus Follicular Dendritic Cell Endothelial Cell Adhesion Molecule Follicular Hyperplasia
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