Advertisement

Morpho-Functional Changes of Follicular Dendritic Cells (FDC) and Lymph Node Structure in Simian Immunodeficiency Virus (SIV) Infection

  • Yury Persidsky
  • Anne-Marie Steffan
  • Jean-Louis Gendrault
  • Cathy Royer
  • Anne-Marie Aubertin
  • Andre Kirn
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 378)

Abstract

The onset of acquired immunodeficiency syndrome (AIDS) has been reported to coincide with destruction the network of follicular dendritic cells (FDC) in germinal centers of lymph nodes (LNs)1. These observations have led to the theory in which one of underlying mechanisms of HIV pathogenesis may be loss of FDC in LNs2. This process can be investigated in rhesus macaque infected with simian immunodeficiency virus (SIV), developing an immunodeficient disease closely resembling AIDS3. Although the specific role of FDC has been recognized in both HIV- and SIV-induced diseases1,4, up to now little is known about morpho-functional changes of these cells during follicular hyperplasia and follicular involution in LNs. Investigating LNs of monkeys infected with SIV we found that morpho-functional peculiarities of FDC were closely related to virus distribution, local cytokine production and structure of lymphoid tissue.

Keywords

Germinal Center Simian Immunodeficiency Virus Follicular Dendritic Cell Endothelial Cell Adhesion Molecule Follicular Hyperplasia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    G. Pantaleo, C.Graziosi, J.F. Demarest, L. Butini, M. Montroni, C.H. Fox, J.M. Orenstein, D.P.Kotlet, and A.S. Fauci, HIV infection is active and progressive in lymphoid tissue during clinically latent stage of disease, Nature 362:355 (1993).PubMedCrossRefGoogle Scholar
  2. 2.
    J.A. Levy, The transmission of HIV and factors influencing progression to AIDS, Am. J. Med. 95:86 (1993).PubMedCrossRefGoogle Scholar
  3. 3.
    P. Fultz, Nonhuman primate models for AIDS, Clin. Infect. Dis. 17 (suppl 1):S230 (1992).CrossRefGoogle Scholar
  4. 4.
    P. Joling, D.F. van Wichen, H.K. Parmentier, P. Biberfeld, D. Bottiger, J. Tchopp, L.H.P.M.Rademakers, and H.J. Schuurman, AIDS Res. Hum. Retroviruses 8:2021 (1992).PubMedCrossRefGoogle Scholar
  5. 5.
    A. Venet, I. Bourgault, A.M. Aubertin, M.P. Kieny, and J.P. Levy, Cytotoxic lymphocyte-T response against simian immunodeficiency virus (A) (SIV) proteins in SIV-infected macaques, J. Immunol. 148:2899 (1992).PubMedGoogle Scholar
  6. 6.
    G. Janossy, M. Boffil, M. Johnson, and P. Racz, Changes of germinal center organization in HIV-1-positive lymph nodes, in:“Accesory cells in HIV and other retroviral infections”, P. Racz, CD. Dijkstra, J.C. Gluckman, ed., Karger, Basel (1991).Google Scholar
  7. 7.
    G. Koopman, H.K. Parmentier, H.J. Schuurman, W. Newman, C.J. Meijer, and S.T. Pals, Adhesion of human B cells to follicular dendritic cells involves both the lymphocyte functional-associated antigen1/intercellular adhesion molecule 1 and very late antigen 4/vascular cell adhesion molecule pathways,/. Exp. Med. 173:1297 (1991).PubMedCrossRefGoogle Scholar
  8. 8.
    L.P. Ruco, D. Pomponi, R. Pigott, A.J.H. Gearing, A. Biocchini, and CD. Baroni, Expression and cell distribution of the intercellular adhesion molecule, vascular cell adhesion molecule, endothelial leukocyte adhesion molecule, and endothelial cell adhesion molecule (CD31)in reactive human lymph nodes and in Hodgkin’s disease, Am. J. Pathol. 140:1337 (1992).PubMedGoogle Scholar
  9. 9.
    D. Emilie, M. Peuchmaur, M.C. Maillot, M.C Crevon, N. Brousse, J.F. Delfraissy, J. Dormont, and P. Galanaud, Production of interleukins in human immunodeficiency virus-1-replicating lymph nodes, J. Clin. Invest. 86:148 (1990).PubMedCrossRefGoogle Scholar
  10. 10.
    J.E. Merril, Cytokines and retroviruses, Clin. Immunol. Immunopathol. 64:23 (1992).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Yury Persidsky
    • 1
  • Anne-Marie Steffan
    • 1
  • Jean-Louis Gendrault
    • 1
  • Cathy Royer
    • 1
  • Anne-Marie Aubertin
    • 1
  • Andre Kirn
    • 1
  1. 1.INSERM U74 and Institut de Virologie de la Faculte de MedicineStrasbourgFrance

Personalised recommendations