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The Monoclonal Antibody FDC-M1 Recognizes Possible Follicular Dendritic Cell Precursors in the Blood and Bone Marrow

  • Stephen T. Haley
  • John G. Tew
  • Andras K. Szakal
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 378)

Abstract

Antigen transport cells (ATC) 1 transport immune complexes to the follicles of draining lymph nodes for longterm retention by the follicular dendritic cell (FDC) antigen-retaining reticulum (ARR). The purpose of this study was to determine the antigenic phenotype of ATC to further explore the relationship of ATC to FDC. For more detail on antigen transport refer to the accompanying paper by Szakal et al., in this volume.

Keywords

Bone Marrow Drain Lymph Node Follicular Dendritic Cell Popliteal Lymph Node Murine Bone Marrow 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    A.K. Szakal, K.L. Holmes, and J.G. Tew, Transport of immune complexes from the subcapsular sinus to lymph node follicles on the surface of nonphagocytic cells, including cells with dendritic morphology, J. Immunol. 131:1714–1727 (1983).PubMedGoogle Scholar
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    C.T. Schnizlein, M.H. Kosco, A.K. Szakal, and J.G. Tew, Follicular dendritic cells in suspension:identification, enrichment, and initial characterization indicating immune complex trapping and lack of adherence and phagocytic activity, J. Immunol. 134:1360–1368 (1985).PubMedGoogle Scholar
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    K Maeda, M.H. Kosco, G.F. Burton, A.K. Szakal, and J.G. Tew, Expression of the intercellular adhesion molecule-1 (ICAM-1) on non-lymphoid cell: interdigitatingcells (IDC), antigen transport cells (ATC), and follicular dendritic cells (FDC), Cell Tissue Res In Press:(1994).Google Scholar
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    M.H. Kosco, A.K. Szakal, and J.G. Tew, Antigenic phenotype of rodent follicular dendritic cells in vitro and in situ, Adv. Exp. Med. Biol. 186:193–202 (1985).Google Scholar
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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Stephen T. Haley
    • 1
  • John G. Tew
    • 2
  • Andras K. Szakal
    • 1
  1. 1.Department of AnatomyMedical College of VirginiaRichmondUSA
  2. 2.Department of Microbiology and ImmunologyMedical College of VirginiaRichmondUSA

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