Skip to main content

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 378))

  • 32 Accesses

Abstract

Dendritic cells (DC) are very efficient antigen presenting cells, distributed in many tissues and organs (1). In the skin, they are characterized by CDla expression and the most extensively studied cell among them is the epidermal Langerhans cell. However, the dermis contains also a population of CDla+ cells with potent antigen presenting capacities (2, 3). It was described by Larsen et al. (4) that Ia+ cells migrated “spontaneously out of murine ear skin into the medium during culture.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Steinman R.M. The dendritic cell system and its role in immunogenecity. Annu Rev Immunol 9:271–296, (1991).

    Article  PubMed  CAS  Google Scholar 

  2. Meunier L., Gonzales-Ramos A., Cooper K.D. Heterogenous populations of Class II MHC+ cells in human dermal cell suspensions. J Immunol 151, 4067–4080, (1993).

    PubMed  CAS  Google Scholar 

  3. Nestle F.O., Xiang-Guang Z., Thompson C.B. et al. Characterization of dermal dendritic cells obtained from normal human skin reveals phenotypic and functionally distinctive subsets. J Immunol 151: 6535–6545, (1993).

    PubMed  CAS  Google Scholar 

  4. Larsen C.P., Steinman R.M., Witmer-Pack M. et al. Migration and maturation of Langerhans cells in skin transplants and explants. J Exp med 172: 1484–1493, (1990).

    Google Scholar 

  5. Richters C.D., Hoefsmit E.C.M., Van Baare J. et al. Isolation and characterization of migratory human skin dendritic cells. Clin Exp Immunol ,98, in press, (1994).

    Google Scholar 

  6. Cordell J.L., Falini B., Erber W.N. et al. Immunoenzymatic labelling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal antialkaline phosphatase (APAAP complexes). J Histochem Cytochem 32: 219–229, (1984).

    Article  PubMed  CAS  Google Scholar 

  7. Bos J.D., Zonneveld I., Das K. et al. The skin immune system (SIS): Distribution and immunophenotype of lymphocyte subpopulations in normal human skin. J Invest Dermatol 88: 569–573, (1987).

    Article  PubMed  CAS  Google Scholar 

  8. Bos J.D., de Boer O.J. Tibosch E. et al. Skin-homing T Lymphocytes: detection of cutaneous lymhocyte antigen (CLA) by HECA-425 in normal human skin. Arch Dermatol Res 285:179–183 (1993).

    Article  PubMed  CAS  Google Scholar 

  9. Inaba K., Romani N., and Steinman R.M. An antigen independent contact mechanism as an early step in T cell-proliferative responses to dendritic cells. J Exp Med 170: 527–542, (1989).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1995 Springer Science+Business Media New York

About this chapter

Cite this chapter

Richters, C.D., Hoekstra, M.J., Hoefsmit, E.C.M., Kamperdijk, E.W.A. (1995). Phenotype of Cells Migrated from Human Skin Explants. In: Banchereau, J., Schmitt, D. (eds) Dendritic Cells in Fundamental and Clinical Immunology. Advances in Experimental Medicine and Biology, vol 378. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1971-3_55

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-1971-3_55

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5811-4

  • Online ISBN: 978-1-4615-1971-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics