Phenotype of Cells Migrated from Human Skin Explants

  • C. D. Richters
  • M. J. Hoekstra
  • E. C. M. Hoefsmit
  • E. W. A. Kamperdijk
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 378)


Dendritic cells (DC) are very efficient antigen presenting cells, distributed in many tissues and organs (1). In the skin, they are characterized by CDla expression and the most extensively studied cell among them is the epidermal Langerhans cell. However, the dermis contains also a population of CDla+ cells with potent antigen presenting capacities (2, 3). It was described by Larsen et al. (4) that Ia+ cells migrated “spontaneously out of murine ear skin into the medium during culture.


Dendritic Cell Human Skin Normal Human Skin CD1a Expression Dermal Dendritic Cell 
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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • C. D. Richters
    • 1
  • M. J. Hoekstra
    • 2
  • E. C. M. Hoefsmit
    • 1
  • E. W. A. Kamperdijk
    • 1
  1. 1.Department of Cell Biology, Faculty of MedicineVrije UniversiteitAmsterdamThe Netherlands
  2. 2.Research DepartmentEuro Skin BankBeverwijkThe Netherlands

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