Abstract
Langerhans cells are epidermal dendritic cells which take up antigens and transport them to paracortical areas in regional draining lymph nodes, where they induce T-lymphocyte activation. According to Moll1, LC’s play a key role in the capture, transport and presentation of leishmania to T cells, and in the initiation of the specific immune response in the mouse version of leishmaniasis. In order to establish a canine model of this disease, we first examined the ability of canine LC’s to migrate to regional lymph nodes in response to cutaneous stimulation.
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References
H. Moll, Epidermal Langerhans cells are critical for immunoregulation of cutaneous leishmaniasis.Immunol. Today. 14, 8:383–296 (1993).
S. Cobbold, S. Meltcafe, Monoclonal antibodies that define canine homologues of human CD antigens :summary of the first international Canine Leukocyte Antigen Workshop. (CLAW) Tissue Antigens. 43:137–154(1994).
M. Cumberbatch, I. Kimber, Phenotypic characteristics of antigen bearing cells in the draining lymph nodes of contact sensitize mice, Immunology. 71:404–410 (1990).
M.L. Kripke, C.G. Munn, A. Jeevan, J. Tang, C. Bucana, Evidence that cutaneous antigen presenting cells migrate to regional lymph nodes during contact sensitization. J. of Immunol. 145:2833–2838 (1990).
P.F. Moore, M.D. Schrenzel, Canine cutaneous histiocytoma represents a Langerhans cell proliferative disorder based on an immunophenotypic analysis, in Proc. ACVP Meeting, Orlando, Florida. 119 (1991).
M.I. Liddington, D.F. Hankins, P.J. Morris, J.M. Austyn, Direct observation of Langerhans cell migration from skin to lymphoid tissue. In Proc. Third International Symposium on dendritic cells in fundamental and clinical Immunology. Annecy. 204 (1994)
E.W.A. Kamperdijk, E.M. Raaymakers, J.S.H. De Leeuw, E.C.M. Hoefsmit, Lymph node macrophages and reticulum cells in the immune response. Cell. Tiss. Res. 192:1–23 (1978).
E.W.A. Kamperdijk, M.L. Kapsenberg, M. Van der Berg, E.C.M. Hoefsmit, Characterization of dendritic cells isolated from normal and stimulated lymph nodes of the rat, Cell. Tiss. Res. 242:469–474 (1985).
I. Silberberg-Sinakin, G.J. Thorbecke, R.L. Baer, S.A. Rosenthal, V. Berezowsky, Antigen bearing Langerhans cells in skin, dermal lymphatics and lymph nodes, Cell. Immunol. 25: 137–151 (1987).
J.M.S. Arkema, I.L. Schadee-Eestermans, D.M. Broekhuis-Fluitsma, E.C.M. Hoefsmit, Localization of class II molecules in storage vesicles, endosomes and lysosomes in human dendritic cells, Immunobiol. 183:396–407(1991).
M.I. Kleijmeer, H.W. Nijman, J.J. Van Hellemond, V.M.J. Oorshot, M. Kast, C.I.M. Melief, H.I. Geuze,Human Langerhans cells and dendritic cells display a lysosomal compartment enriched in MHC class II, in proc. Third International Symposium on dendritic cells in fundamental and clinical Immunology. Annecy, 198 (1994).
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Marchal, T., Dezutter-Dambuyant, C., Bourdoiseau, G., Magnol, JP., Schmitt, D. (1995). Evidence that Langerhans Cells Migrate to Regional Lymph Nodes During Experimental Contact Sensitization in Dogs. In: Banchereau, J., Schmitt, D. (eds) Dendritic Cells in Fundamental and Clinical Immunology. Advances in Experimental Medicine and Biology, vol 378. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1971-3_49
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DOI: https://doi.org/10.1007/978-1-4615-1971-3_49
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