Abstract
Dendritic cells (DCs) are highly specialized antigen presenting cells (APCs) initiating primary T-lymphocyte associated immune responses1. DCs are located in many non-lymphoid tissues and a specialized form of DCs - the Langerhans cells (LCs) - is found in the skin. Here they fulfill their in vivo functions by capturing antigens in the epidermis and presenting these antigens to T-lymphocytes in a HLA-restricted way2. Until now the small numbers of functional active LCs which could be isolated from human skin were the limiting factor in this field of research3.
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Degwert, J., Steckel, F., Hoppe, U. (1995). Antigen Presenting and Primary in Vitro Sensitizing Capacity of CD1a+ Dendritic Cells Generated from Human Blood. In: Banchereau, J., Schmitt, D. (eds) Dendritic Cells in Fundamental and Clinical Immunology. Advances in Experimental Medicine and Biology, vol 378. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1971-3_41
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DOI: https://doi.org/10.1007/978-1-4615-1971-3_41
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