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Population Dynamics and Functions of Respiratory Tract Dendritic Cells in the Rat

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Dendritic Cells in Fundamental and Clinical Immunology

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 378))

Abstract

The epithelial surfaces of the respiratory tract are continuously exposed to environmental antigens, and the maintenance of immunological homeostasis in this vital organ system requires efficient local mechanism for antigen surveillance, both in the steady state and during episodes of inflammatory stimulation.

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References

  1. P.G. Holt, M.A. Schon-Hegrad, and P.G. McMenamin. Dendritic cells in the respiratory tract, Intern. Rev. Immunol. 6:139 (1990).

    Article  CAS  Google Scholar 

  2. P.G. Holt. Regulation of antigen-presenting function(s) in lung and airway tissues, Eur. Respir. 7.6:120(1993).

    CAS  Google Scholar 

  3. D.J. Nelson, C. McMenamin, A.S. McWilliam, M. Brenan, and P.G. Holt.Development of the airway intraepithelial Dendritic Cell network in the rat from class II MHC (la) negative precursors: differential regulation of la expression at different levels of the respiratory tract, J. Exp. Med. 179:203 (1994).

    Article  PubMed  CAS  Google Scholar 

  4. P.G. Holt, and M.A. Schon-Hegrad. Localisation of T cells, macrophages and dendritic cells in rat respiratory tract tissue: implications for immune function studies, Immunology 62:349 (1987).

    PubMed  CAS  Google Scholar 

  5. P.G. Holt, M.A. Schon-Hegrad, and J. Oliver. MHC class II antigen-bearing dendritic cells in pulmonary tissues of the rat. Regulation of antigen presentation activity by endogenous macrophage populations, J. Exp. Med. 167:262 (1988).

    Article  PubMed  CAS  Google Scholar 

  6. P.G. Holt, M.A. Schon-Hegrad, J. Oliver, B.J. Holt, and P.G. McMenamin. A contiguous network of dendritic antigen-presenting cells within the respiratory epithelium, Int. Arch. Allergy Appl. Immunol. 91:155 (1990).

    Article  PubMed  CAS  Google Scholar 

  7. M.A. Schon-Hegrad, J. Oliver, P.G. McMenamin, and P.G. Holt. Studies on the density, distribution, and surface phenotype of intraepithelial class II major histocompatibility complex antigen (Ia)-bearing dendritic cells (DC) in the conducting airways, J. Exp. Med. 173:1345 (1991).

    Article  PubMed  CAS  Google Scholar 

  8. J.L. Gong, K.M. McCarthy, J. Telford, T. Tamatani, M. Miyasaka, and E.E. Schneeberger. Intraepithelial airway dendritic cells: a distinct subset of pulmonary dendritic cells obtained by microdissection, J. Exp. Med. 175:797 (1992).

    Article  PubMed  CAS  Google Scholar 

  9. P.G. Holt, M.A. Schon-Hegrad, M.J. Phillips, and P.G. McMenamin. Ia-positive dendritic cells form a tightly meshed network within the human airway epithelium, Clin. Exp. Allergy 19:597 (1989).

    Article  PubMed  CAS  Google Scholar 

  10. R.L. Kradin, K.M. McCarthy, W.J. Xia, D. Lazarus, and E.E. Schneeberger. Accessory cells of the lung. I. Interferon-gamma increases Ia+ dendritic cells in the lung without augmenting their accessory activities. Am. J. Respir. Cell Mol. Biol. 4:210(1991).

    PubMed  CAS  Google Scholar 

  11. C.E. Havenith, A.J. Breedijk, and E.C. Hoefsmit. Effect of Bacillus Calmette-Guerin inoculation on numbers of dendritic cells in bronchoalveolar lavages of rats, Immunobiology 184:336 (1992).

    Article  PubMed  CAS  Google Scholar 

  12. M.A. Casolaro, J.F. Bernaudin, C. Saltini, V.J. Ferrans, and R.G. Crystal. Accumulation of Langerhans’ cells on the epithelial surface of the lower respiratory tract in normal subjects in association with cigarette smoking, Am. Rev. Respir. Dis. 137:406 (1988).

    PubMed  CAS  Google Scholar 

  13. P.G. Holt, J. Oliver, C. McMenamin, and M.A. Schon-Hegrad. Studies on the surface phenotype and functions of dendritic cells in parenchymal lung tissue of the rat, Immunology 75:582 (1992).

    PubMed  CAS  Google Scholar 

  14. W.J. Xia, E.E. Schneeberger, K. McCarthy, and R.L. Kradin. Accessory cells of the lung. II. Ia+ pulmonary dendritic cells display cell surface antigen heterogeneity, Am. J. Respir. Cell Mol. Biol. 5:276 (1991).

    PubMed  CAS  Google Scholar 

  15. P.G. Holt, J. Oliver, N. Bilyk, C. McMenamin, P.G. McMenamin, G. Kraal, and T.Thepen. Downregulation of the antigen presenting cell function(s) of pulmonary dendritic cells in vivo by resident alveolar macrophages, J. Exp. Med. 177:397 (1993).

    Article  PubMed  CAS  Google Scholar 

  16. R.M. Steinman. The dendritic cell system and its role in immunogenicity, Annu. Rev.Immunol. 9:271 (1991).

    Article  PubMed  CAS  Google Scholar 

  17. T. Thepen, C. McMenamin, B. Girn, G. Kraal, and P.G. Holt. Regulation of IgE production in presensitised animals: In vivo elimination of alveolar macrophages preferentially increases IgE responses to inhaled allergen., Clin. Exp. Allergy 22:1107(1992).

    Article  PubMed  CAS  Google Scholar 

  18. P.G. Holt, S. Haining, D.J. Nelson, and J.D. Sedgwick. Origin and steady-state turnover of class II MHC-bearing Dendritic Cells in the epithelium of the conducting airways, J. Immunol. 153:256 (1994).

    PubMed  CAS  Google Scholar 

  19. S. Fossum. Dendritic Leukocytes: features of their in vivo physiology, Res. Immunol.140:877 (1989).

    Article  Google Scholar 

  20. A.S. McWilliam, D. Nelson, J.A. Thomas, and P.G. Holt. Rapid Dendritic Cell recruitment is a hallmark of the acute inflammatory response at mucosal surfaces, J. Exp. Med. 179:1331(1994).

    Article  PubMed  CAS  Google Scholar 

  21. C.E.G. Havenith, P.P.M.C. van Miert, A.J. Breedijk, R.H.J. Beelen, and E.C.M.Hoefsmit. Migration of Dendritic Cells into the draining lymph nodes of the lung after intratracheal instillation, Am. J. Respir. Cell Mol. Biol. 9:484 (1993).

    PubMed  CAS  Google Scholar 

  22. K.M. McCarthy, J.L. Gong, J.R. Telford, and E.E. Schneeberger. Ontogeny of Ia+ accessory cells in fetal and newborn rat lung, Am. J. Respir. Cell Mol. Biol. 6:349 (1992).

    PubMed  CAS  Google Scholar 

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© 1995 Springer Science+Business Media New York

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Holt, P.G., Nelson, D.J., McWilliam, A.S. (1995). Population Dynamics and Functions of Respiratory Tract Dendritic Cells in the Rat. In: Banchereau, J., Schmitt, D. (eds) Dendritic Cells in Fundamental and Clinical Immunology. Advances in Experimental Medicine and Biology, vol 378. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1971-3_39

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  • DOI: https://doi.org/10.1007/978-1-4615-1971-3_39

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5811-4

  • Online ISBN: 978-1-4615-1971-3

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