Abstract
Previous studies demonstrated the presence of a small number of dendritic cells (DC), approximately 1%, in the peritoneal cavity of rats (1). Upon stimulation with either specific (e.g. Bacillus Calmette-Guérin, BCG) or non-specific stimuli (e.g. Thioglycollate Broth, TG) the number of DC had increased to 3% (2). Different studies demonstrated the superior capacity of peritoneal DC compared to peritoneal macrophages (MΦ) to present the antigen glutamine-tyrosine (GT) to GT-primed T cells in an in vitro assay (1,2,3), which is in agreement with other studies (4). Intraperitoneal stimulation with different stimuli had no effect on the antigen presenting capacity of DC, whereas that of the MΦ decreased, and especially after BCG M∅ had a suppressive effect on T cell proliferation. From these studies it was concluded that in the peritoneal cavity the DC was the major APC and although M∅ can act as APC, this function of M∅ strongly depends on the state of inflammation.
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van Vugt, E., van Pelt, M., Beelen, R.H.J., Kamperdijk, E.W.A. (1995). Migration of Rat Dendritic Cells and Macrophages from the Peritoneal Cavity to the Parathymic Lymph Nodes. In: Banchereau, J., Schmitt, D. (eds) Dendritic Cells in Fundamental and Clinical Immunology. Advances in Experimental Medicine and Biology, vol 378. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1971-3_36
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DOI: https://doi.org/10.1007/978-1-4615-1971-3_36
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