Abstract
Evidence deriving from studies in the mouse showed that Langerhans cells (LC) capture antigens encountered in the epidermis and migrate subsequently from the epidermis to the skin-draining lymph nodes where they efficiently present antigens to T cells1,2,3. To migrate from epidermis to regional lymph nodes, antigen-bearing epidermal Langerhans cells must move through extracellular matrix (ECM) of various composition. The basement membrane (BM) of human skin presents a barrier rich in laminin (LM), type IV collagen, nidogen and heparan sulfate proteoglycans. The ECM of the superficial dermis contains interstitial collagens I and III essentially. Fibronectin (FN) is encountered mainly in afferent lymphatics. The effects of these ECM molecules on the LC behavior remain poorly understood.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Kimber and M. Cumberbatch, Dendritic cells and cutaneous immune responses to chemical allergens, Toxicol Appl. Pharmacol. 117:137 (1992).
M.L. Kripke, C.G. Munn, A. Jeevan, J-M. Tang, and C. Bucana, Evidence that cutaneous antigenpresenting cells migrate to regional lymph nodes during contact sensitization, J. Immunol. 145:2833 (1990).
S.E. Macatonia, S.C. Knight, A.J. Edwards, S. Griffiths, and P. Fryer, Localization of antigen on lymph node dendritic cells after exposure to the contact sensitizer fluorescein isothiocyanate. Functional and morphological studies. J. Exp. Med. 166:1654 (1987).
B. LeVarlet, M.J. Staquet, C. Dezutter-Dambuyant, P. Delorme, and D. Schmitt, In vitro adhesion of human Langerhans cells to laminin and fibronectin occurs through 61 integrin receptors. J. Leukoc. Biol. 51:415 (1992).
B. LeVarlet, C. Dezutter-Dambuyant, M.J. Staquet, P. Delorme, and D. Schmitt, Human epidermal Langerhans cells express integrins of the 61 subfamily. J. Invest. Dermatol. 96:518 (1991).
N. Romani, A. Lenz, H. Glassel, H. Stössel, U. Stanzi, O. Majdic, P. Fritsch, G. Schuler, Cultured human Langerhans cells resemble lymphoid dendritic cells in phenotype and function. J. Invest. Dermatol. 93:600 (1989).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1995 Springer Science+Business Media New York
About this chapter
Cite this chapter
Staquet, MJ., Kobayashi, Y., Jacquet, C., Dezutter-Dambuyant, C., Schmitt, D. (1995). Role of the Interaction of Fibronectin with Epidermal Langerhans Cells in Regulating Their Migratory Pathway. In: Banchereau, J., Schmitt, D. (eds) Dendritic Cells in Fundamental and Clinical Immunology. Advances in Experimental Medicine and Biology, vol 378. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1971-3_31
Download citation
DOI: https://doi.org/10.1007/978-1-4615-1971-3_31
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-5811-4
Online ISBN: 978-1-4615-1971-3
eBook Packages: Springer Book Archive