Skip to main content
SpringerLink
Log in

Expression of the High Affinity Receptor for Immunoglobulin E (IgE) by Dendritic Cells in Normals and Asthmatics

  • Chapter
Dendritic Cells in Fundamental and Clinical Immunology

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 378))

Abstract

Immunoglobulin E (IgE) plays an important role in the pathophysiology of asthma and other allergic diseases. In mucosal tissues, IgE binds to specific receptors on the surface of mast cells, eosinophils and other inflammatory cells providing an important trigger mechanism for the release of inflammatory mediators.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. B.J.Sutton and H.J Gould, The human IgE network, Nature366:421 (1993).

    Article  PubMed  CAS  Google Scholar 

  2. W.O.C.M. Cookson,Maternal inheritance of atopic IgE responsiveness on chromosome 11q, Lancet340:381(1992).

    Article  PubMed  CAS  Google Scholar 

  3. A.J. Sandford, T.Shirakaewa, M.F. Moffatt, S.E. Daniels, C.Ra, J.A. Faux, R.P. Young, Y. Nakamura, G.M. Lathrop, W.O.C.M. Cookson and J.M.Hopkin, Localisation of atopy and ß subunit of high affinity IgEreceptor (FcεRI) on chromosome 11q, Lancet341:332 (1993).

    Article  PubMed  CAS  Google Scholar 

  4. T. Bieber, H. dela Salle, A. Wollenberg, J. Hakimi, R. Chizzonite, J. Ring, D. Hanau and C. dela Salle, Human epidermal Langerhans cellsexpress the high affinity receptor for immunoglobulin E (FcεRI), J.Exp. Med175:1285 (1992).

    Article  PubMed  CAS  Google Scholar 

  5. B. Wang, A.Rieger, O. Kilgus, K. Ochiai, D. Maurer, D. Födinger, J-P. Kinet and G. Stingl,Epidermal Langerhans cells from normal humanskin bind monomelic IgE via FcεRI, J. Exp. Med175:1353(1992).

    Article  PubMed  CAS  Google Scholar 

  6. K.M. Britten, P.H. Howarth and W.R. Roche, Immunohistochemistry onresin sections: a comparison of resin embedding techniques for small mucosalbiopsies, Biotech. Histochem68:271 (1993).

    Article  PubMed  CAS  Google Scholar 

  7. A. Bellini, E.Vittori, M. Marini, V. Ackerman and S. Mattoli, Intraepithelial dendritic cellsand selective activation of Th2-like lymphocytes in patients with atopicasthma, Chest103:997 (1993).

    Article  PubMed  CAS  Google Scholar 

  8. W.J. Fokkens,C.A.F.M. Bruijnzeel-Koomen, T.H.M. Vroom, E. Rijntje, E.C.M. Hoefsmit, G.C.Mudde and P.L.B. Bruijnzeel, The Dendritic cell: an underestimated cell inatopic disease, Clin. Exp. Allergy20:627 (1990).

    Article  PubMed  CAS  Google Scholar 

  9. T. Bieber, FcεRI on human Langerhans cells: a receptor in search of newfunctions, Immunol. Today 15:52 (1994).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Centre Block, Level D, General Hospital, University Medicine, Southampton, SO16 6YD, UK

    Amanda E. Semper, Judith A. Hartley, J. Manuel Tunon-de-Lara, Peter Bradding, Anthony E. Redington, Martin K. Church & Stephen T. Holgate

  2. Service de Maladies Respiratoires, Hôpital du Haut Lévêque, Centre Hospitalier Universitaire de Bordeaux, F 33604, Pessac, France

    J. Manuel Tunon-de-Lara

Authors
  1. Amanda E. Semper
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Judith A. Hartley
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. Manuel Tunon-de-Lara
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Peter Bradding
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Anthony E. Redington
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Martin K. Church
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Stephen T. Holgate
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Laboratory for Immunological Research, Schering-Plough, Dardilly, France

    Jacques Banchereau

  2. INSERM U346, Hôpital Edouard Herriot, Lyon, France

    Daniel Schmitt

Rights and permissions

Reprints and permissions

Copyright information

© 1995 Springer Science+Business Media New York

About this chapter

Cite this chapter

Semper, A.E. et al. (1995). Expression of the High Affinity Receptor for Immunoglobulin E (IgE) by Dendritic Cells in Normals and Asthmatics. In: Banchereau, J., Schmitt, D. (eds) Dendritic Cells in Fundamental and Clinical Immunology. Advances in Experimental Medicine and Biology, vol 378. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1971-3_29

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-1971-3_29

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5811-4

  • Online ISBN: 978-1-4615-1971-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation