Distribution of Human Colonic Dendritic Cells and Macrophages - Functional Implications
Luminal antigens that have penetrated into the intestinal lamina propria, interact with different components of the immune system including dendritic cells and macrophages. Dendritic cells are potent immunostimulatory cells and can take up and present both intestinally and orally administered antigens to naive T cells1,2. Intestinal macrophages also ingest antigen, but often have an immunosuppressive function: they either inhibit the effect of dendritic cells (mouse3), or have no detectable action (human4). Mucosa-associated macrophages in other systems have similar suppressive effects on immune responses in vitro and in vivo5–7.
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