Distribution of Human Colonic Dendritic Cells and Macrophages - Functional Implications

  • Paul Pavli
  • Lesley Maxwell
  • Erika van de Pol
  • William F. Doe
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 378)


Luminal antigens that have penetrated into the intestinal lamina propria, interact with different components of the immune system including dendritic cells and macrophages. Dendritic cells are potent immunostimulatory cells and can take up and present both intestinally and orally administered antigens to naive T cells1,2. Intestinal macrophages also ingest antigen, but often have an immunosuppressive function: they either inhibit the effect of dendritic cells (mouse3), or have no detectable action (human4). Mucosa-associated macrophages in other systems have similar suppressive effects on immune responses in vitro and in vivo5–7.


Dendritic Cell Alveolar Macrophage Lamina Propria Sucrose Phosphate Mature Macrophage 
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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Paul Pavli
    • 1
  • Lesley Maxwell
    • 1
  • Erika van de Pol
    • 1
  • William F. Doe
    • 1
  1. 1.Division of Clinical Sciences, John Curtin School of Medical ResearchAustralian National University at Woden Valley HospitalWodenAustralia

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