Functional CD40 Antigen on B Cells, Dendritic Cells and Fibroblasts
During antigen specific immune responses, antigen specific naive B cells undergo a cascade of events including activation, expansion, mutations, isotype switch, selections and differentiation into either antibody secreting plasma cells or memory B cells. These antigendependent events occur in different areas of secondary lymphoid organs, as well as other non-lymphoid organs. It requires the interaction of B cells with antigens and numerous cell types including T cells, dendritic cells (DC) and follicular dendritic cells (FDC). These cells interact with B cells through different cell surface molecules and through the release of polypeptidic mediators called cytokines.
KeywordsArthritis Cystein Germinal Immobilization Polypeptide
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