Abstract
Human aldose reductase (hAR), an NADPH-dependent enzyme, catalyzes the reversible reduction of a wide variety of carbonyl-containing compounds to their respective alcohol counterparts (Flynn and Green, 1993). Although a physiological role for this enzyme has not yet been established, inhibitors of hAR appear to be effective in the treatment of diabetic neuropathy (Masson and Boulton, 1990).
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References
Bash, P.A., Field, M.J., Davenpor, R.C., Petsko, G.A., Ringe, D., and Karplus, M., 1991, Computer Simulation and Analysis of the Reaction Pathway of Triosephosphate Isomerase, Biochemistry 30:5826–5832.
Bohren, K.M., Bullock, B., Wermuth, B., and Gabbay, K.H., 1989, The Aldo-Keto Reductase Superfamily. cDNAs and Deduced Amino Acid Sequences of Human Aldehyde and Aldose Reductases, J. Biol. Chem. 264:9547–9551.
De Winte, H.L., and von Itzstein, M,1994, submitted (Biochemistry).
Flynn, T.G., and Green, N.C., 1993, The aldo-keto reductases: an overview, in: Enzymology and Molecular Biology of Carbonyl Metabolism 4:251–257. Edited by H. Weiner, Plenum Press, New York.
Masson, E. A., and Boulton, A. J.M., 1990, Aldose Reductase Inhibitors in the Treatment of Diabetic Neuropathy. A Review of the Rationale and Clinical Evidence, Drugs 39:190–202.
Taylor, N.R., and von Itzstein, M., 1994, Molecular Modeling Studies on Ligand Binding to Sialidase from Influenza Virus and the Mechanism of Catalysis, J. Med. Chem. 37:616–624.
Vander Jagt, D.L., Robinson, B., Taylor, K.K., and Hunsaker, L.A., 1992, Reduction of Trioses by NADPH-de-pendent Aldo-Keto Reductases, J. Biol. Chem. 267:4364–4369.
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© 1995 Springer Science+Business Media New York
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De Winter, H.L., von Itzstein, M. (1995). Molecular Modelling Calculations on the Binding of D- and L-Xylose to Wild-Type Aldose Reductase and its H110Q and H110A Mutants. In: Weiner, H., Holmes, R.S., Wermuth, B. (eds) Enzymology and Molecular Biology of Carbonyl Metabolism 5. Advances in Experimental Medicine and Biology, vol 372. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1965-2_28
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DOI: https://doi.org/10.1007/978-1-4615-1965-2_28
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