Abstract
Cytosolic class-3 aldehyde dehydrogenases have been the subject of extensive investigation in recent years because they are demonstrated determinants of cellular sensitivity to certain widely used anticancer drugs, namely, cyclophosphamide, ifosfamide, 4-hydroperoxycyclophosphamide and mafosfamide (cellular sensitivity to these drugs decreases as the cellular concentration of cytosolic class-3 aldehyde dehydrogenase increases) [Bunting and Townsend, 1993; Sreerama and Sladek, 1993a,b, 1994a; Rekha et al., 1994; Sreerama et al., 1994a], and because they may aid in protecting cells by catalyzing the detoxification of otherwise toxic aldehydes arising from lipid peroxidation therein [reviewed in Lindahl, 1992]. Moreover, it has been proposed that corneal cytosolic class-3 aldehyde dehydrogenase protects the eye against UV-B lightinduced damage, in part, by directly absorbing it [Downes et al., 1994 and references cited therein]. Of particular interest, for obvious reasons, is the regulation of their expression, particularly as such regulation is influenced by environmental, dietary and therapeutic agents.
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Sladek, N.E., Sreerama, L., Rekha, G.K. (1995). Constitutive and Overexpressed Human Cytosolic Class-3 Aldehyde Dehydrogenases in Normal and Neoplastic Cells/Secretions. In: Weiner, H., Holmes, R.S., Wermuth, B. (eds) Enzymology and Molecular Biology of Carbonyl Metabolism 5. Advances in Experimental Medicine and Biology, vol 372. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1965-2_14
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DOI: https://doi.org/10.1007/978-1-4615-1965-2_14
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