Abstract
Genetic defects in humans have greatly improved our insight in the function of genes controlling the lipoprotein metabolism. A good example is the apolipoprotein (APO) E gene, for which both dominant and recessive mutations have been observed. These findings have clearly established an important role for apoE in lipoprotein remnant metabolism1. In contrast, mutations within the APOCI gene have not been observed hampering insight in the in vivo function of apoC1.
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References
R.W. Mahley, T.L. Innerarity, S.C. Rall, Jr, K.H. Weisgraber, and J.M. Taylor, Apolipoprotein E: genetic variants provide insight into its structure and function, Curr. Opin. Lipid. 1:87–95 (1990).
A.K. Soutar, C.W. Garner, H.N. Bakker, J.T. Sparrow, R.L Jackson, A.M. Gotto, and L.C. Smith, Effect of the human plasma apolipoproteins and phosphatidylcholine acyl donor on the activity of lecithin:acyltransferase, Biochem. 14:3057–3064 (1975).
K.H. Weisgraber, R.W. Mahley, R.C. Kowall, J. Herz, J.L. Goldstein, and M.S. Brown, J. Biol. Chem. 265:22453–22459 (1990).
M.J.V. Hoffer, M.H. Hofker, M.M. van Eck, L.M. Havekes, and R.R. Frants, Evolutionary conservation of the mouse apolipoprotein E - Cl - C2 genecluster; structure and genetic variability in inbred mice. Genomics, 15:62–67 (1993).
M.M. van Eck MM, M.J.V Hoffer, L.M. Havekes, R.R. Frants, and M.H. Hofker, Detection of a new gene within the mouse apolipoprotein e-cl-c2 gene cluster, Genomics (in press).
M.J.V. Hoffer, M.M. van Eck, L.M. Havekes, M.H. Hofker, and R.R. Frants, The mouse apolipoprotein Cl gene: structure and expression. Genomics, 18:37–42 (1993).
J.H. van Ree, W.J.A.A. van den Broek, V.E.H. Dahlmans, P.H.E. Groot, M. Vidgeon-Hart, R.R. Frants, B. Wieringa, L.M. Havekes, and M.H. Hofker, Diet-induced hypercholesterolemia and atherosclerosis in heterozygous apolipoprotein E-deficient mice, Atherosclerosis (in press).
B. van Vlijmen, A.M.J.M. van den Maagdenberg, M. Gijbels, H. van der Boom, R.R Frants, M.H. Hofker, and L.M. Havekes, Diet induced hyperlipipoproteinemia and atherosclerosis in transgenic APOE3-Leiden mice J. Clin. Invest. 93: 1403–1410 (1994).
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© 1995 Springer Science+Business Media New York
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Hofker, M.H. et al. (1995). Generation and Characterization of Apolipoprotein Cl-Deficient Mice. In: Gallo, L.L. (eds) Cardiovascular Disease. GWUMC Department of Biochemistry Annual Spring Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1959-1_39
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DOI: https://doi.org/10.1007/978-1-4615-1959-1_39
Publisher Name: Springer, Boston, MA
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