Generation and Characterization of Apolipoprotein Cl-Deficient Mice

  • Marten H. Hofker
  • Janine H. van Ree
  • Walther J. A. A. van der Broeck
  • Jan M. A. van Deursen
  • Hans van der Boom
  • Rune R. Frants
  • Bé Wieringa
  • Louis M. Havekes
Chapter
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)

Abstract

Genetic defects in humans have greatly improved our insight in the function of genes controlling the lipoprotein metabolism. A good example is the apolipoprotein (APO) E gene, for which both dominant and recessive mutations have been observed. These findings have clearly established an important role for apoE in lipoprotein remnant metabolism1. In contrast, mutations within the APOCI gene have not been observed hampering insight in the in vivo function of apoC1.

Keywords

Cholesterol Sucrose Recombination Triglyceride Thymidine 

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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Marten H. Hofker
    • 1
  • Janine H. van Ree
    • 1
    • 2
  • Walther J. A. A. van der Broeck
    • 3
  • Jan M. A. van Deursen
    • 3
  • Hans van der Boom
    • 2
  • Rune R. Frants
    • 1
  • Bé Wieringa
    • 3
  • Louis M. Havekes
    • 2
  1. 1.MGC-Department of Human GeneticsLeiden UniversityLeidenThe Netherlands
  2. 2.Gaubius LaboratoryPG-TNOLeidenThe Netherlands
  3. 3.Department of Cell Biology and HistologyNijmegen UniversityNijmegenThe Netherlands

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