Apo A-I Containing Particles and Atherosclerosis
Epidemiological and clinical studies showing an association between decreased concentrations of high-density-lipoprotein (HDL) cholesterol and increased risk of premature coronary artery disease (CAD)1,2 have generated interest in the mechanism through which HDL prevents atherosclerosis. The HDL have been historically defined as lipoproteins with densities between 1.063 and 1.20 g/ml3. Human HDL consists of a collection of particles differing in size, density and apolipoprotein content4. Over the years, ultracentrifugation and, subsequently, polyanion precipitation and gradient gel electrophoresis have been used to fractionate HDL into subclasses5. Recognition of the importance of the apolipoproteins (apo) not only in the formation and structural stability of lipoproteins but also in their metabolism has led to the separation of HDL into further subpopulations according to their apolipoprotein composition rather than their physicochemical properties.
KeywordsCholesterol Efflux Lipoprotein Particle Peripheral Cell Adipose Cell Premature Coronary Artery Disease
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