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Gene Therapy in Heart Disease

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Nutrition and Biotechnology in Heart Disease and Cancer

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 369))

Abstract

Interest in gene therapy arises from the realization that, for many human diseases, current treatment of human disease, genetic or otherwise, is generally aimed at symptoms or secondary defects and almost never at the precise biochemical or genetic disease itself. The ideal treatment could involve actual change or replacement of defective genes (Friedman, 1983). In spite of remarkable surgical and pharmaceutical advances, therapy of the more than 5000 genetic disorders is not a clinical reality. The most effective drugs act, not only in the target organ, but also in other tissues, where they produce side effects. Moreover, drugs are expensive and must be continued for lifetime. Gene therapy is an alternative to a lifetime of medication, particularity when effective drugs do not exist.

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Authors and Affiliations

  1. Department of Cell Biology, Baylor College of Medicine, Houston, TX, 77030-3498, USA

    Louis C. Smith, Randy C. Eisensmith & Savio L. C. Woo

  2. Department of Medicine, Baylor College of Medicine, Houston, TX, 77030-3498, USA

    Louis C. Smith & Savio L. C. Woo

  3. Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX, 77030-3498, USA

    Savio L. C. Woo

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  1. Louis C. Smith
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  2. Randy C. Eisensmith
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Editors and Affiliations

  1. University of North Carolina, Chapel Hill, North Carolina, USA

    John B. Longenecker

  2. Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania, USA

    David Kritchevsky

  3. Duke University Medical Center, Durham, North Carolina, USA

    Marc K. Drezner

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Smith, L.C., Eisensmith, R.C., Woo, S.L.C. (1995). Gene Therapy in Heart Disease. In: Longenecker, J.B., Kritchevsky, D., Drezner, M.K. (eds) Nutrition and Biotechnology in Heart Disease and Cancer. Advances in Experimental Medicine and Biology, vol 369. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1957-7_8

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  • DOI: https://doi.org/10.1007/978-1-4615-1957-7_8

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