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Nutrition and Carcinogenesis: Historical Highlights and Future Prospects

  • R. K. Boutwell
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 369)

Abstract

Gene therapy for cancer is on the horizon and gene prophylaxis is likely under specific circumstances. However, prevention, or at least a lowered risk of developing cancer is possible now. The knowledge to accomplish prevention is based primarily on laboratory research with experimental animals. The basic principles of carcinogenesis, nutrition, and intermediary metabolism do not differ in most cases between nonhuman animals and people. There is every reason to be certain that most of the facts established in laboratories are effective for the prevention of cancer in people.

Keywords

Retinoic Acid Caloric Restriction Mammary Carcinogenesis Stock Diet Ornithine Decarboxylase Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Ashendel, C.L., and Boutwell, R.K., 1979, Prostaglandin E and F levels in mouse epidermis are increased by tumor-promoting phorbol esters, Biochem. Biophys. Res. Commun. 90:623.CrossRefGoogle Scholar
  2. Baumann, C.A., Jacobi, H., and Rusch, H.P., 1939, The effects of diet on experimental tumor production, Am. J. Hyg. 30:1.Google Scholar
  3. Baumann, C.A., and Rusch, H.P., 1939, Effect of diet on tumors induced by ultraviolet light, Am. J. Cancer 35:213.Google Scholar
  4. Belman, S., 1983, Onion and garlic oils inhibit tumor promotion, Carcinogenesis 4:1063.CrossRefGoogle Scholar
  5. Belman, S., Solomon, J., Segal, A., Block, E., and Barany, G., 1989, Inhibitors of soybean lipoxygenase and mouse skin tumor promotion by onion and garlic components, J. Biochem. Toxicol. 4:151.CrossRefGoogle Scholar
  6. Benson, A.M., Batzinger, R.P., Ou, S.-Y.L., Bueding, E., Cha, Y.-N., and Talalay, P., 1978, Elevation of hepatic glutathione S-transferase activities and protection against mutagenic metabolites of benzo[a] pyrene by dietary antioxidants. Cancer Res. 38:4486.Google Scholar
  7. Bischoff, F., and Long, M.L., 1938, The influence of calories per se upon the growth of sarcoma 180, Am. J. Cancer 32:418.Google Scholar
  8. Boissonneault, G.A., Elson, C.A., and Pariza, M.W., 1986, Net energy effects of dietary fat on chemically induced mammary carcinogenesis in F-344 rats, J. Natl. Cancer Inst. 76:335.Google Scholar
  9. Bollag, W., 1971, Therapy of chemically induced skin tumors of mice with vitamin A palmitate and vitamin A acid [retinoic acid], Experimentia 27:90.CrossRefGoogle Scholar
  10. Bollag, W., 1972, Prophylaxis of chemically induced benign and malignant epithelial tumors by vitamin A acid (retinoic acid). Eur. J. Cancer 8:689.Google Scholar
  11. Boutwell, R.K., 1964, Some biological aspects of skin carcinogenesis, Prog. Exptl. Tumor Res. 4:207.Google Scholar
  12. Boutwell, R.K., Brush, M.K., and Rusch, H.P., 1948, Some physiological effects associated with chronic caloric restrictions. Am. J. Physiol. 154:517.Google Scholar
  13. Boutwell, R.K., Brush, M.K., and Rusch, H.P., 1949, The influence of vitamins of the B-complex on the induction of epithelial tumors in mice, Cancer Res. 9:747.Google Scholar
  14. Braden, L.M., and Carroll, K.K., 1986, Dietary polyunsaturated fat in relation to mammary carcinogenesis in rats, Lipids 21:285.CrossRefGoogle Scholar
  15. Cohen, S.M., Wittenberg, J.F., and Bryan, G.T., 1976, Effect of avitaminosis A and hypervitaminosis A on urinary bladder carcinogenicity of N-[4-(nitro-2-furyl)-2-thiazolyl] formamide, Cancer Res. 36:2334.Google Scholar
  16. Emerick, R.J., Zile, M, and DeLuca, H.F., 1967, Formation of retinoic acid from retinol in the rat, Biochem J. 102:606.Google Scholar
  17. Engle, R.W., and Copeland, D.H., 1952. Protective action of stock diets against cancer-inducing action of 2-acetylaminofluorene in rats. Cancer Res. 12:211.Google Scholar
  18. Gali, H.V., Perchellet, E.M., Klish, D.S., Johnson, S.M., and Perchellet, J.-P., 1992, Antitumor-promoting activities of hydrolyzablc tannins in mouse skin, Carcinogenesis 13:715.CrossRefGoogle Scholar
  19. Griffin, A.C., and Jacobs, M.M. 1977, Effects of selenium on azo dye hepatocarcinogenesis, Cancer Lett. 3:177.CrossRefGoogle Scholar
  20. Hartman, P.E., and Shankel, D.M., 1990, Antimutagens and anticarcinogenesis: a survey of putative interceptor molecules, Environmental Mol. Mutagenesis 15:145.CrossRefGoogle Scholar
  21. Hayashi, Y., Nagao, M., Sugimura, T., Takayama, S., Tomatis, L., Wattenberg, L.W., and Wogan, G.N., 1986. Diet, Nutrition and Cancer. Princess Takamatsu Symposium, vol. 16, Japan Societies Press, Tokyo.Google Scholar
  22. Hecht, S.S., Morse, M.A., Shantu, A., Stoner, G.D., Jordan, K.G., Choi, C.-I., and Chung, F.-L., 1989, Rapid single-dose model for lung tumor induction in A/J mice by 4-(methylnitrosoamino)-1-(3-pyridyl)-1-butanone and the effect of diet, Carcinogenesis 10:1901.CrossRefGoogle Scholar
  23. Huang, M.-T., Smart, R.C., Wong, C.-Q., and Conney, A.H., 1988, Inhibitory effect of curcumin, chlorogenic acid, caffeic acid, and ferrulic acid on tumor promotion in mouse skin by 12-O-tetradecanoylphorbol-13-acetate. Cancer Res. 48:5941.Google Scholar
  24. IARC Monographs on the Evaluation of Carcinogenic Risk to Humans, 1993, Some Naturally Occurring Substances: Food Items and Constituents. Heterocyclic Aromatic Amines, and Mycotoxins, vol. 56.Google Scholar
  25. Ip, C., 1981, Prophylaxis of mammary neoplasia by selenium supplementation in the initiation and promotion phase of chemical carcinogenesis, Cancer Res. 41:4386.Google Scholar
  26. Ip, C., 1987, Fat and essential fatty acid in mammary carcinogenesis, Am. J. Clin. Nutr. 45:218.Google Scholar
  27. Ip, C., Chin, S.F., Scimeca, J.A., and Pariza, M.W., 1991, Mammary cancer prevention by conjugated dienoic derivative of linoleic acid. Cancer Res. 51:6118.Google Scholar
  28. Ip, C., and Ganther, H.E., 1990. Activity of methylated forms of selenium in cancer prevention. Cancer Res. 50:1206.Google Scholar
  29. Ip, C., and Ganther, H.E., 1992. Comparison of selenium and sulfur analogs in cancer prevention, Carcinogenesis 13:1167.CrossRefGoogle Scholar
  30. Jacobi, H.P., and Baumann, C.A., 1940. The effect of fat on tumor formation. Am. J. Cancer 39:338.Google Scholar
  31. Jacobs, M.M., Jansson, B., and Griffin, A.C., 1977, Inhibitory effects of selenium on 1,2-dimethylhydrazine and methylazoxymethanol acetate induction of colon tumors, Cancer Lett. 2:133.CrossRefGoogle Scholar
  32. Klurfeld, D.M., Welch, C.B., Davis, M.J., and Kritchevsky, D., 1989, Determination of degree of energy restriction necessary to reduce mammary tumorigenesis in rats during the promotion phase, J. Nutr. 119:286.Google Scholar
  33. Kritchevsky, D., and Klurfeld, D.M., 1987. Caloric effects in experimental mammary tumorigenesis. Am. J. Clin. Nutr. 45:236.Google Scholar
  34. Kuroda, Y., Shankel, D.M., and Waters, M.D., 1990, “Antimutagenesis and Anticarcinogenesis, Mechanisms II” Basic Life Sciences, vol. 52, Plenum Press, New York and London.Google Scholar
  35. Larsen, C.D., 1945, Effects of cystine and calorie restriction on the incidence of spontaneous pulmonary tumors in strain A mice, J. Natl. Cancer Inst. 6:31.Google Scholar
  36. Lavik, P.S., and Baumann, C.A., 1941. Dietary fat and tumor formation, Cancer Res. 1:181.Google Scholar
  37. Lavik, P.S., and Baumann, C.A., 1943. Further studies on the tumor promoting action of fat, Cancer Res. 3:749.Google Scholar
  38. LePage, G.A., Potter, V.R., Busch, H., Heidelberger, C., and Hurlbert, R.B., 1952, Growth of carcinoma implants in fed and fasted rats. Cancer Res. 12:153.Google Scholar
  39. Liu, J., Gilbert, K., Parker, H.M., Hashek, W.M., and Milner, J.A., 1991, Inhibition of 7,12-dimethylbenz[a]anthracene-induced mammary tumors and DNA adducts by dietary selenite, Cancer Res. 51:4613.Google Scholar
  40. McCay, C.M., Crowell, M.F., and Maynard, L.A., 1935, The effect of retarded growth upon the length of the life span and upon the ultimate body size, J. Nutr. 10:63.Google Scholar
  41. McCay, C.M., Ellis, G.H., Barnes, L.L., Smith, C.A.H., and Spewling, G., 1939, Chemical and pathological changes in aging and after retarded growth, J. Nutr. 18:15.Google Scholar
  42. Messina, M.J., Persky, V., Setchell, K.D.R., and Barnes, S., 1994, Soy intake and cancer risk: a review of in vitro and in vivo data, Nutrition and Cancer 21:113.CrossRefGoogle Scholar
  43. Miller, E.C., and Miller, J.A., 1979, Miletones in Chemical Carcinogenesis, Seminars in Oncology 6:445.Google Scholar
  44. Miller, E.C., and Miller, J.A., 1979, Naturally occurring chemical carcinogens that may be present in food, in “Biochemistry of Nutrition IA,” A. Neuberger and T.H. Jakes, eds., University Park Press, Baltimore.Google Scholar
  45. Miller, E.C., Miller, J.A., Hirono, I., Sugimura, T., and Takayama, S., 1979, Naturally Occurring Carcinogens-Mutagens and Modulators of Carcinogenesis, Japan Scientific Societies Press, Tokyo.Google Scholar
  46. Milner, J.A., 1989, Mechanism for nutritional inhibition of cancer, in “Nutrition and Cancer Prevention, Investigating the Role of Micronutrients,” T.E. Moon and M.S. Micozzi, eds., Marcel Decker, New York.Google Scholar
  47. Moon, R.C., McCormick, D.L., and Mehta, R.G., 1983, Inhibition of carcinogenesis by retinoids, Cancer Res. 43:2469.Google Scholar
  48. Moreschi, C., 1909, Beziehungen zwischen emährung und tumorwachstum, Z. Immunitsforsh. 2:651.Google Scholar
  49. Mottram, J.C., 1944, A developing factor for experimental blastogenesis, J. Path. Bact. 56:181.CrossRefGoogle Scholar
  50. Nelson, A.A., Fitzhugh, O.G., and Calvery, H.O., 1943, Liver tumors following cirrhosis caused by selenium in rats. Cancer Res. 3:230.Google Scholar
  51. Pariza, M.W., and Felton, J.S., 1990. Mutagens and Carcinogens in the Diet, Wiley-Liss, New York.Google Scholar
  52. Reddy, B.S., and Maeura, Y., 1984. Tumor promotion by dietary fats in azoxymethane-induced colon carcinogenesis in female F344 rats: influence of amount and source of dietary fat, J. Natl. Cancer Inst. 72:745.Google Scholar
  53. Roebuck, B.D., Yager, J.D., Longnecker, D.S., and Wilpone, S.A., 1981, Promotion by unsaturated fat of azaserine-induced pancreatic carcinogenesis in the rat, Cancer Res. 41:3961.Google Scholar
  54. Rous, P., 1914, The influence of diet on transplanted and spontaneous mouse tumors, J. Exptl. Med. 20:433.CrossRefGoogle Scholar
  55. Rowland, I.R., 1991. Nutrition, Toxicity and Cancer, CRC Press, Boca Raton, FL.Google Scholar
  56. Rusch, H.P., Kline, B.E., and Baumann, C.A., 1945, The influence of caloric restriction and of dietary fat on tumor formation with ultraviolet radiation, Cancer Res. 5:431.Google Scholar
  57. Saffiotti, U., Montesano, R., SellaKumar, A.R., and Borg, S.A., 1967, Experimental cancer of the lung. Inhibition by vitamin A of the induction of trachealbronchial metaplasia and squamous cell tumors, Cancer 20:857.CrossRefGoogle Scholar
  58. Saxton, J.A., Boon, M.C. and Furth, J., 1944, Observations on the inhibition of the development of spontaneous leukemia in mice by underfeeding, Cancer Res. 4:401.Google Scholar
  59. Scott, M.L., 1973, The selenium dilemma, J. Nutr. 103:803.Google Scholar
  60. Shamsuddin, A.M., Elsayed, A.M., and Ullah, A., 1988, Suppression of large intestinal cancer in F344 rats by inositol hexaphosphate, Carcinogenesis 9:577.CrossRefGoogle Scholar
  61. Silverstone, H., Solomon, R.D., and Tannenbaum, A., 1952, Relative influences of natural and semipurified diets on tumor formation in mice. Cancer Res. 12:750.Google Scholar
  62. Sivertsen, I., and Hastings, W.H., 1938. A preliminary report on the influence of food and function on the incidence of mammary gland tumor in A stock albino mice, Minn. Med. 21:873.Google Scholar
  63. Sparnins, V.L., Barany, G., and Wattenberg, L., 1988, Effects of organo-sulfur compounds from garlic and onions on benzo[a]pyrene-induced neoplasia and glutathione-S-transferase activity, Carcinogenesis 9:131.CrossRefGoogle Scholar
  64. Sparnins, V.L., and Wattenberg, L.W., 1981, Enhancement of glutathione S-transferase activity of the mouse forestomach by inhibitors of benzo[a]pyrene-induced neoplasia of this anatomic site, J. Natl. Cancer Inst. 66:769.Google Scholar
  65. Takigawa, M., Verma, K., Simsiman, R.C., and Boutwell, R.K., 1983, Inhibition of mouse skin tumor promotion and of promoter-stimulated epidermal polyamine synthesis by α-difluoromethylornithine. Cancer Res. 43:3732.Google Scholar
  66. Tannenbaum, A., 1940, The initiation and growth of tumors. I. Effects of underfeeding, Am. J. Cancer 38:335.Google Scholar
  67. Tannenbaum, A., 1942, The genesis and growth of tumors. III. Effects of a high fat diet, Cancer Res. 2:468.Google Scholar
  68. The Alpha-tocopherol, Beta-carotene Cancer Prevention Study Group, 1994, The effect of vitamin E and beta-carotene on the incidence of lung cancer and other cancers in male smokers. New Eng. J. Med. 330:1029.CrossRefGoogle Scholar
  69. Vanderhoek, J. Y., Makheja, A. R., and Bailey, J. M., 1980, Inhibition of fatty acid oxygenases by onion and garlic oils, Biochem. Pharmacol. 29:3169.CrossRefGoogle Scholar
  70. Verma, A.K., 1989, Inhibition of phorbol ester-induced ornithine decarboxylase gene transcription by retinoic acid: a possible mechanism of antitumor promoting action of retinoids, Prog. Clin. Biol. Res. 259:245.Google Scholar
  71. Verma, A.K., Ashendel, C.L., and Boutwell, R.K., 1980, Inhibition by prostaglandin synthesis inhibitors of the induction of epidermal ornithine decarboxylase activity, the accumulation of prostaglandins, and tumor promotion caused by 12-0-tetradecanoylphorbol-13-acetate, Cancer Res. 40:308.Google Scholar
  72. Verma, A.K., and Boutwell, R.K., 1977, Vitamin A acid (retinoic acid), a potent inhibitor of 12-0-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase activity in mouse epidermis, Cancer Res. 37:2197.Google Scholar
  73. Verma, A.K., Rice, K.M., and Boutwell, R.K., 1977, Prostaglandins and skin tumor promotion: inhibition of tumor promoter-induced ornithine decarboxylase activity in epidermis by inhibitors of prostaglandin synthesis, Biochem. Biophys. Res. Commun. 79:1160.CrossRefGoogle Scholar
  74. Verma, A.K., Shapas, B.G., Rice, H.M., and Boutwell, R.K., 1979, Correlation of the inhibition by retinoids of tumor promoter-induced epidermal ornithine decarboxylase activity and of skin tumor promotion. Cancer Res. 39:419.Google Scholar
  75. Visscher, M.B., Ball, Z.B., Barnes, R.H., and Sivertsen, I., 1942, The influence of caloric restriction upon the incidence of spontaneous mammary carcinoma in mice, Surgery 11:48.Google Scholar
  76. Volk, M.J., Pugh, T.D., Moon, J.K., Frith, C.H., Daynes, R.A., Ershler, W.B., and Weindruch, R., 1994, Dietary restrictions from middle age attenuates age-associated lymphoma development and IL-6 deregulation in C57BL/6 mice. Cancer Res. 54:May 15 issue.Google Scholar
  77. Wargovich, M.J., Woods, C., Eng, V.W.S., Stephens, L.C., and Gray, K., 1988, Chemoprevention of N-nitrosomethylbenzylamine-induced esophageal cancer in rats by the naturally occurring thioether, diallylsulfide. Cancer Res. 48:6872.Google Scholar
  78. Watson, A.F., and Mellanby, E., 1930. Tar cancer in mice II: the condition of the skin when modified by external treatment or diet, as a factor influencing the cancerous reaction, Brit. J. Exptl. Path. 11:311.Google Scholar
  79. Wattenberg, L.W., 1971. Studies of polycyclic hydrocarbon hydroxylases of the intestine possibly related to cancer. Effect of diet on benzpyrene hydroxylase activity, Cancer 28:99.CrossRefGoogle Scholar
  80. Wattenberg, L.W., 1977, Inhibition of carcinogenic effects of polycyclic hydrocarbons by benzylisothiocyanate and related compounds, J. Natl. Cancer Inst. 58:395.Google Scholar
  81. Wattenberg, L.W., 1987. Inhibitory effects of benzylisotheocyanate administered shortly before diethylnitrosamine or benzo[a]pyrene on pulmonary and forestomach neoplasia in A/J mice, Carcinogenesis 8:1971.CrossRefGoogle Scholar
  82. Wattenberg, L.W., 1992a, Inhibition of carcinogenesis by minor dietary constituents. Cancer Res. (Suppl.) 52:2085s.Google Scholar
  83. Wattenberg, L.W., 1992b. Chemoprevention of cancer by naturally occurring and synthetic compounds, in “Cancer Chemoprevention,” L. Wattenberg, M. Lipkin, C.W. Boone, and G.J. Kelloff, eds., CRC Press, Inc., Boca Raton, FL.Google Scholar
  84. Wattenberg, L.W., Coccia, J.B., and Lam, L.K.T., 1980, Inhibitory effects of phenolic compounds on benzo[a]pyrene-induced neoplasia, Cancer Res. 40:2820.Google Scholar
  85. Weindruch, R., Albanes, D., and Kritchevsky, D., 1991, The role of calories and caloric restriction in cancer, Hematol./Oncol. Clinics No. America 5:79.Google Scholar
  86. Weindruch, R., and Walford, R.L., 1982. Dietary restriction in mice beginning at 1 year of age: effects on life span and spontaneous cancer incidence, Science 215:1415.CrossRefGoogle Scholar
  87. Welsch, C.W., House, J.L., Herr, B.L., Eliasberg, S.S., and Welsch, M.A., 1990, Enhancement of mammary carcinogenesis by high levels of dietary fat: a phenomenon dependent on ad libitum feeding, J. Natl. Cancer Inst. 82:1615.CrossRefGoogle Scholar
  88. Willett, W.C., 1994, Diet and health: what should we eat?, Science 264:532.CrossRefGoogle Scholar
  89. Wilt, S., Pereira, M., and Couri, D., 1979, Selenium effect on initiation and promotion of tumors by benzo[a]pyrene and 12-0-tetradecanoylphorbol, Proc. Am. Assoc. Cancer Res. 20:21.Google Scholar
  90. Wolbach, S.B., and Howe, P.R., 1925, Tissue changes following deprivation of fat soluble A vitamin, J. Exptl. Med. XLII:753.CrossRefGoogle Scholar
  91. Zhang, Y., Kensler, T.W., Cho, C-G., Posner, G.H., and Talalay, P., 1994, Proc. Natl. Acad. Sci. 91:3147.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • R. K. Boutwell
    • 1
  1. 1.Department of OncologyUniversity of Wisconsin Medical SchoolMadisonUSA

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