Abstract
Opioid receptors were first detected on the cells of the nervous system (1,2). Using radiolabeled ligands, cell lines developed from cells of the immune system have been shown to express the kappa opiate receptor (3,4). One example is the R1.1 T-thymoma developed from a C58/J mouse. This cell line has been shown to express the surface markers Thy 1.2 and H-2 k(5). This cell line has also been shown to express the kappa receptor by receptor binding assays (4). Little is known about the differentiation stage or functional capacity of this T cell line.
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References
Nakanishi, S., Inoue, A., Kita, T., Nakamura, M., Chang, A.C.Y., Cohen, S.N., & Numa, S. (1979). Nucleotide sequence of cloned cDNA for bovine corticotrophin-ß-lipotropin precursor. Nature 278, 423–427.
Robson, L.E., Paterson, S.J., & Kosterlitz, H.W. (1983). Opiate receptors. Handbk. Psychopharmacol. 17, 13–80.
Carr, D.J.J., Kim, C.-H., DeCosta, B.R., Jacobson, A.E., Rice, K.C., & Blalock, J.E. (1988). Evidence for kappa-class opioid receptors on cells of the immune system. Cell. Immunol. 116, 44–51.
Bidlack, J.M., Saripalli, L.D., & Lawrence, D.M.P. (1992). Kappa-opioid binding sites on a murine lymphoma cell line. Eur. J. Pharmacol. Mol. Pharmacol. Sect. 227, 257–265.
Ralph, P. (1973). Retention of lymphocyte characteristics by myelomas and thetatlymphomas: sensitivity to cortisol and phytohemagglutinin. J. Immunol. 110, 1470–1475.
Wang, A.M., Doyle, M.V., & Mark, D.F. (1989). Quantification of mRNA by the polymerase chain reaction. Proc. Natl. Acad. Sci. USA 86, 9717–9721.
Yasuda, K., Raynor, K., Kong, H., Breder, C.D., Takeda, J., Racine, T., & Bell, G.I. (1993). Cloning and functional comparison of kappa and delta opioid receptors from mouse brain. Proc. Natl. Acad. Sci. USA 90, 6736–6740.
Shortman, K., Egarton, M., Spangrude, G.J., & Scollay, R. (1990). The generation and fate of thymocytes. Semin. Immunol. 2, 3–12.
Mathieson, B.J., & Fowlkes B.J. (1984). Cell surface expression on thymocytes: development and phenotypic differentiation of intra thythic subsets. Immunol. Rev. 82, 141–173.
Kingston, R., Jenkinson, E.J., & Owen, J.J.T. (1985). A single stem cell can recolonize an embryonic thymus. Nature 317, 811–813.
Bessler, H., Sztein, M.B., & Serrate, S.A. (1990). β-Endorphin modulation of IL-1-induced IL-2 production. Immunopharmacology 19, 5–14.
Peterson, P.K., Sharp, B., Gekker, G., Brummitt, C., & Keane, W.F. (1987). Opioid-mediated suppression of interferon-γ production by cultured peripheral blood mononuclear cells. J. Clin. Invest. 80, 824–831.
van den Bergh, P., Rozing, J., & Nagelkerken, L. (1993). P-Endorphin stimulates Ia expression on mouse B cells by inducing interleukin-4 secretion by CD4+ T cells. Cell. Immunol. 149, 180–192.
van den Bergh, P., Dobber, R., Ramlal, S., Rozing, J., & Nagelkerken, L. (1994). Role of opioid peptides in the regulation of cytokine production by murine CD4+ T cells. Cell. Immunol. 154, 109–122.
Fischer, E.G. (1988). Opioid peptides modulate immune functions. A review. Immunopharmacol. Immunotoxicol. 10, 256–326.
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Belkowski, S.M., Zhu, J., Liu-Chen, L.Y., Eisenstein, T.K., Adler, M.W., Rogers, T.J. (1995). Detection of К-Opioid Receptor mRNA in Immature T Cells. In: Sharp, B.M., Eisenstein, T.K., Madden, J.J., Friedman, H. (eds) The Brain Immune Axis and Substance Abuse. Advances in Experimental Medicine and Biology, vol 373. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1951-5_2
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DOI: https://doi.org/10.1007/978-1-4615-1951-5_2
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