Abstract
It is well established that in vivo administration of morphine to rats produces alterations in several in vitro measures of immune status. For example, our work has shown that the administration of morphine to Lewis rats induces a dose-dependent reduction in the proliferative response of splenic and blood lymphocytes, a reduction in the production of interleukin-2 and γ-interferon, and a reduction in the cytotoxic response of natural killer cells. Furthermore, we have shown that administration of the opioid antagonist, naltrexone, dose-dependently antagonizes the immunomodulatory effects of morphine, indicating that the immunomodulatory effects of morphine are mediated by activity at opioid receptors1.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
D.T. Lysle, M.E. Coussons, V.J. Watts, E.H. Bennett, and L.A. Dykstra. Morphine-induced alterations of immune status: Dose-dependency, compartment specificity, and antagonism by naltrexone. Journal of Pharmacology and Experimental Therapeutics,265:1071 (1993).
Y. Shavit, A. DePaulis, F.C. Martin, G.W. Terman, R.N. Pechnick, C.J. Zane, R.P. Gale and J.C. Liebeskind, Involvement of brain opiate receptors in the immune-suppressive effect of morphine, PNAS 83:7114 (1986).
R.J. Weber and A. Pert, The periaqueductal grey matter mediates opiate-induced immunosuppression, Science 245:188 (1989).
L.J. Luecken, and D.T. Lysle. Evidence for the involvement of 13-adrenergic receptor in conditioned immunomodulation. Journal of Neuroimmunology, 38:209 (1992).
D.T. Lysle, J.E. Cunnick, H. Fowler, and B.S. Rabin. Pavlovian conditioning of shock-induced suppression of lymphocyte reactivity: Acquisition, extinction, and preexposure effects. Life Sciences, 42:2185 (1988).
D.T. Lysle, J.E. Cunnick, B.J. Kucinski, H. Fowler, and B.S. Rabin. Characterization of immune alterations induced by a conditioned aversive stimulus. Psychobiology, 18:220 (1990).
D.T. Lysle, L.J. Luecken, and K.A. Maslonek. Modulation of immune status by a conditioned aversive stimulus: Evidence for the involvement of endogenous opioids. Brain, Behavior, and Immunity, 6:179 (1992).
K. Fecho, L.A. Dykstra, and D.T. Lysle. Evidence for β-adrenergic receptor involvement in the immunomodulatory effects of morphine. Journal of Pharmacology and Experimental Therapeutics, 265:1079 (1993).
R.M.J. Palmer, A. G. Ferrige, and S. Moncada. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 327:524 (1987).
K. Shibuki, and D. Okada. Endogenous nitric oxide release required for long-term synaptic depression in the cerebellum. Nature, 349:326 (1991).
P. Vincendeau, S. Daulouede, B. Veyret, M.L. Darde, B. Bouteille, and J.L. Lemesre. Nitric oxide-mediated cytostatic activity on Trypanosoma brucei gambiense and Ttypanosoma brucei brucei. Experimental Parasitology, 75:353 (1992).
C.D. Mills, J. Shearer, R. Evans, and M.D. Caldwell. Macrophage arginine metabolism and the inhibition or stimulation of cancer. J. Immunol., 149:2709 (1992).
S.J. Green, C.A. Nacy, and M.S. Meltzer. Cytokine-induced synthesis of nitrogen oxides in macrophages: A protective host response to Leishmania and other intracellular pathogens. Journal of Leukocyte Biology, 50:93 (1991).
S. J. Green, M.S. Meltzer, J.B. Hibbs, and C.A. Nacy. Activated macrophages destroy intracellular Leishmania major amastigotes by an L-arginine-dependent killing mechanism. Journal of Immunology, 144:278 (1990).
S.L. James, and J. Glaven. Macrophage cytotoxicity against schistosomula of Schistosoma mansoni involves arginine-dependent production of reactive nitrogen intermediates. Journal of Immunology, 143:4208 (1989).
J.E. Albina, J.A. Abate, and W.L. Henry. Nitric oxide production is required for murine resident peritoneal macrophages to suppress mitogen-stimulated T cell proliferation. Journal of Immunology, 147:144 (1991).
J.E. Albina, C.D. Mills, W.L. Henry, and M.D. Caldwell. Regulation of macrophage physiology by L-arginine: role of the oxidative L-arginine deiminase pathway. J. Immunol, 143:3641 (1989).
J.E. Albina, and W.L. Henry. Suppression of lymphocyte proliferation through the nitric oxide synthesizing pathway. Journal of Surgical Research, 50:403 (1991).
D.W. Pascual, V.H. Pascual, K.L. Bost, J.R. McGhee and S. Oparil. Nitric oxide mediates immune dysfunction in the spontaneously hypertensive rat. Hypertension, 21:185 (1992).
Y. Fu, and E.P. Blankenhorn. Nitric oxide-induced anti-mitogenic effects in high and low responder strains. Journal of Immunology, 148:2217 (1992).
K. Fecho, K.A. Maslonek, M.E. Coussons-Read, L.A. Dykstra, and D.T. Lysle. Macrophage-derived nitric oxide is involved in the depressed concanavalin A responsiveness of splenic lymphocytes from rats administered morphine in vivo. Journal of Immunology, 152:5845 (1994).
M.E. Coussons-Read, K.A. Maslonek, K. Fecho, L. Perez, and D.T. Lysle. Evidence for the involvement of macrophage-derived nitric oxide in the modulation of immune status by a conditioned aversive stimulus. Journal of Neuroimmunology, 50:51 (1994).
J.B. Hibbs, Z. Vavrin, and R.R. Taintor. L-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells. J. Immunol. 138:550 (1987).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1995 Springer Science+Business Media New York
About this chapter
Cite this chapter
Lysle, D.T., Fecho, K., Maslonek, K.A., Dykstra, L.A. (1995). Evidence for the Involvement of Macrophage-Derived Nitric Oxide in the Immunomodulatory Effect of Morphine and Aversive Pavlovian Conditioning. In: Sharp, B.M., Eisenstein, T.K., Madden, J.J., Friedman, H. (eds) The Brain Immune Axis and Substance Abuse. Advances in Experimental Medicine and Biology, vol 373. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1951-5_19
Download citation
DOI: https://doi.org/10.1007/978-1-4615-1951-5_19
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-5801-5
Online ISBN: 978-1-4615-1951-5
eBook Packages: Springer Book Archive