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The Clastogenicity of Morphine Sulfate in vivo

  • David B. Couch
  • Satin G. Sawant
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 373)

Abstract

An opioid analgesic, morphine, and an opioid peptide, β-endorphin, have been shown to induce chromosome damage, as indicated by an increased frequency of micronucleated lymphocytes, following acute administration to mice. The genotoxic response is opioid receptor-mediated and is abolished in adrenalectomized animals. Further, plasma from morphine-treated animals also induces micronuclei formation in naive lymphocytes in vitro; this response is blocked by inclusion the steroid antagonist RU 486 in the incubation mixture. In addition to the steroid-mediated production of chromosome damage, morphine acts directly on lymphocytes to enhance the clastogenicity of acutely administered cyclophosphamide in manner consistent with depressed DNA repair capacity.

Keywords

Chromosome Damage Morphine Sulfate Cytogenetic Damage Murine Lymphocyte Adrenalectomized Animal 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • David B. Couch
    • 1
  • Satin G. Sawant
    • 1
  1. 1.Department of Pharmacology and ToxicologyUniversity of Mississippi Medical CenterJacksonUSA

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