Abstract
In former studies clinical trials have been performed to test the possibilities to differentiate between different types of eye melanomas i.e. spindle cell and mixed/epitheloid cell types melanomas using ultrasound methods (Romijn et al. 1991, Thijssen et al. 1991). The latter type is much more malignant than the first type. In these studies a sensitivity and a specificity of differentiation of about 90 % was reached. However, when correlations between the acoustical parameters and the histology of the tumours were investigated, hardly any correlation was found. This means that the underlying acoustical models were not adequate. The present project was started to investigate in detail the acoustical properties of biological tissues. The measurements in this project were performed in vitro at frequencies between 10 and 55 MHz. These frequencies are higher than the frequencies used in the clinical study (7.5 MHz), but still low enough to relate the results to those of the clinical study.
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van der Steen, A.F.W., Thijssen, J.M., van der Laak, J.A.W.M., de Wilde, P.C.M., Ebben, G.P.J. (1995). Correlation of Histology and Acoustic Parameters of Liver Tissue by Scanning Acoustic Microscopy. In: Jones, J.P. (eds) Acoustical Imaging. Acoustical Imaging, vol 21. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1943-0_59
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DOI: https://doi.org/10.1007/978-1-4615-1943-0_59
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