Advertisement

The Production of TNF, IL-1 And IL-6 in Cutaneous Tissues During Maturation and Aging

  • Stanislava S. Stosic-Grujicic
  • Miodrag L. Lukic
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 371)

Abstract

Epithelial cells (EC) resident to cutaneous tissues are important producers of various immunostimulatory, proinflammatory and inhibitory cytokines1,2 Locally produced cytokines in epithelial tissues mediate events relevant to growth, differentiation and function of surrounding cells. Based on their capacity to induce various cell adhesion molecules, as well as “secondary” cytokines,3 they play an important role in intercellular communications. Since immunocompetence of epithelial tissues may be influenced by maturation and aging,4-6 the aim of the present study was to obtain more information on the age-related changes of production of relevant cytokines. To examine this, we investigated age-related expression of TNF, IL-1 and IL-6 by comparing secretory potential of EC normally resident to skin of fetal, neonatal and adult rats.

Keywords

Cutaneous Tissue Secretory Potential Relevant Cytokine Epidermal Cell Culture Compromise Wound Healing 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. S. Stosic-Grujicic and M. L. Lukic, Immunology 75: 293 (1992).PubMedGoogle Scholar
  2. C. F. Bigler, D. A. Norris, W. L. Weston, and W. P. Arrend, J. Invest. Dermatol 98: 38 (1992).PubMedCrossRefGoogle Scholar
  3. T. S. Kupper, J. Clin.. Invest. 86: 1783 (1990).PubMedCrossRefGoogle Scholar
  4. D. N. Sauder, B. M. Stanulis-Praeger, and B. A. Gilchrest, Arch. Dermatol Res. 280: 71 (1988).PubMedCrossRefGoogle Scholar
  5. D. V. Belsito, S. P. Epstein, J. M. Schultz, R. L. Bear, and G. J. Thorbecke, J. Immunol 143: 1530 (1989).PubMedGoogle Scholar
  6. C. D. Dijkstra, E. P. Van Rees, and E. A. Döpp, in:“Histophysiology of the Immune System”, S. Fossum, and B. Rolstad, (eds.), p. 731, Plenum Press, New York and London (1988).CrossRefGoogle Scholar
  7. S. Stosic-Grujicic, D. J. Lalosevic, and M. L. Lukic, Int. J. Immunopharmac. 9: 577 (1987).CrossRefGoogle Scholar
  8. S. F. Orencole and C. A. Dinarello, Cytokine 1: 14 (1989).PubMedCrossRefGoogle Scholar
  9. L. A. Aarden, E. R. De Groot, L. O. Schaap, and P. M. Landsdorp, Eur. J. Immunol 17: 1411 (1987).PubMedCrossRefGoogle Scholar
  10. S. K. Burchett, W. M. Weaver, J. A. Westall, A. Larsen, S. Kronheim, and C. B. Wilson, J. Immunol 140: 3473 (1988).PubMedGoogle Scholar
  11. S. Stosick-Grujicic, V. Stankovic, and M. L. Lukic, in:“Lymphatic Tissue and In vivo Immune Responses”, S. Ezine, S. Berrih-Akinin, and B. Imhof, (eds.), p. 321, Marcel Dekker Inc., NY (1991).Google Scholar
  12. J. C. Ansel, T. A. Luger, D. Lowry, P. Perry, D. R. Roop, and J. D. Mounts, J. Immunol 140: 2274 (1988).PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Stanislava S. Stosic-Grujicic
    • 1
  • Miodrag L. Lukic
    • 2
  1. 1.Institute for Biologica ResearchSchool of Medicine University of BelgradeBelgradeYugoslavia
  2. 2.Institute of Microbiology and ImmunologySchool of Medicine University of BelgradeBelgradeYugoslavia

Personalised recommendations