Abstract
Intestinal epithelial cells (IEC) are known to secrete a variety of important cytokines including the inflammatory cytokine interleukin-6 (IL-6).1,2 Along with its role in the inflammatory response, IL-6 has also been shown to act as a co-stimulator for T cell proliferative responses3 and is known to induce Peyer’s patch and appendix B cells to secrete high levels of IgA.4, 5 Therefore, the IEC, through its secretion of IL-6, has the potential to be a very important factor in inflammation and IgA immune responses at the intestinal mucosa.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
L. Mayer, E. Siden, S. Becker and D. Eisenhardt, Antigen handling in the intestine mediated by normal enterocytes, In: “Advances in Mucosal Immunology: Proceedings of the 5th International Congress of Mucosal Immunology,” T. MacDonald, S. J. Challacombe, P. W. Bland, C. R. Stokes, R. V. Heatley, and A. Mcl Mowat, eds., Kluwer Academic Publishers, Boston, MA (1990).
D. W. McGee, K. W. Beagley, W. K. Aicher and J. R. McGhee, Immunology. 76: 7 (1992).
S. Akira, T. Hirano, T. Taga and T. Kishimoto, FASEB J. 4: 2860 (1990).
K. W. Beagley, J. H. Eldridge, F. Lee, H. Kiyono, M. P. Everson, W. J. Koopman, T. Hirano, T. Kishimoto and J. R. McGhee, J. Exp. Med. 169: 2133 (1989).
K. Fujihashi, J. R. McGhee, C. Lue, K. W. Beagley, T. Taga, T. Hirano, T. Kishimoto, J. Mestecky and H. Kiyono, J. Clin. Invest. 88: 248 (1991).
S. M. Wahl, J. Clin. Immunol. 12: 61 (1992).
R. L. Coffman, D. A. Lebman and B. Shrader, J. Exp. Med. 170: 1039 (1989).
E. Sonoda, R. Matsumoto, Y. Hitoshi, T. Ishii, M. Sugimoto, S. Araki, A. Tominaga, N. Yamaguchi and K. Takatsu, J. Exp. Med. 170: 1415 (1989).
N. Pierce and J. Gowans, J. Exp. Med. 142: 1550 (1975).
C. O. Elson and W. Ealding, J. Immunol. 132: 2736 (1984).
N. Lycke and J. Holmgren, Immunology. 59: 301 (1986).
J. Van Snick, S. Cayphas, A. Vink, C. Uyttenhove, P. G. Coulie, M. R. Rubira and R. J. Simpson, Proc. Natl. Acad. Sci. USA. 83: 9679 (1986).
T. Mossman, J. Immunol. Methods. 65: 55 (1983).
K. Mitsuyama, E. Sasaki, A. Toyonaga, H. Ikeda, O. Tsuruta, A. Irie, N. Arima, T. Oriishi, K. Harada, K. Fujisaki, M. Sata and K. Tanikawa, Digestion. 50: 104 (1991).
J. E. Crabtree, T. M. Shallcross, R. V. Heatley and J. I. Wyatt, Gut. 32: 1473 (1991).
D. Rachmilewitz, P. L. Simon, L. W. Schwartz, D. E. Griswold, J. D. Fondacaro and M. A. Wasserman, Gastroenterology. 97: 326 (1989).
M. Ligumsky, P. L. Simon, F. Karmeli and D. Rachmilewitz, Gut. 31: 686 (1990).
M. Kurokowa, K. Lynch and D. K. Podolsky, Biochem. Biophys. Res. Comm. 142: 775 (1987).
S. J. McKenzie and J. F. Halsey, J. Immunol. 133: 1818 (1984).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1995 Springer Science+Business Media New York
About this chapter
Cite this chapter
McGee, D.W., McGhee, J.R., Beagley, K.W., Aicher, W.K. (1995). The Regulation of IL-6 Secretion from IEC-6 Intestinal Epithelial Cells by Cytokines and Mucosally Important Antigens. In: Mestecky, J., Russell, M.W., Jackson, S., Michalek, S.M., Tlaskalová-Hogenová, H., Šterzl, J. (eds) Advances in Mucosal Immunology. Advances in Experimental Medicine and Biology, vol 371. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1941-6_47
Download citation
DOI: https://doi.org/10.1007/978-1-4615-1941-6_47
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-5796-4
Online ISBN: 978-1-4615-1941-6
eBook Packages: Springer Book Archive