B-Cell Promoting Activity of Human Colostrum

  • Igor I. Slukvin
  • Valentina V. Pilipenko
  • Victor P. Chernyshov
  • Alexey A. Philchenkov
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 371)


It is well known that human colostrum and milk contain different factors which provide passive immunization for newborn infants.1–3 However, recently it has been shown that human milk may serve as a mechanism by which active immunity can be transferred to the recipient newborn. Free secretory component (SC), lactoferrin, and S-IgA were described as suppressor factors in human colostrum.4–6 At the same time, clinical data suggest the presence in human colostrum and milk of factors, that enhance Ig production. In this paper we have assessed the effect of human colostrum on B cell function of mouse splenocytes. A high-performance liquid chromatography (HPLC) gel-filtration was employed to identify the fraction that associated with B cell-promoting activity of human colostrum.


Human Milk Bovine Colostrum Globulin Fraction Suboptimal Dose Mouse Splenocytes 
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  1. 1.
    L. A. Hanson, S. Ahelstedt, B. Andersson, B. Carlsson, S. Fallstrom, L. Mellander, O. Porras, T. Soderstrom, and C. Svanborg, Pediatrics 75, suppl. 1: 172 (1985).Google Scholar
  2. 2.
    P. L. Ogra, M. Fishaut, and C. Theodore, in: “Human Milk, its Biological and Social Value”, S. Freier and A. I. Edelman, eds., p. 115, Shaare Zedek Medical Center, Jersualem (1980).Google Scholar
  3. 3.
    V. Chernishov and I. Slukvin, Arch. Immunol. Therap. Exp. 38: 145 (1990).Google Scholar
  4. 4.
    S. S. Crago, R. Kulhavy, S. J. Prince, and J. Mestecky, Clin. Exp. Immunol. 45: 386 (1981).PubMedGoogle Scholar
  5. 5.
    E. Richie, J. Hillard, R. Gilmore, and D. Gillespie, J. Reprod. Immunol. 12: 137 (1987).PubMedCrossRefGoogle Scholar
  6. 6.
    K. Komiyama, S. S. Crago, K. Itoh, I. Moro, and J. Mestecky, Cell. Immunol. 101: 143 (1986).PubMedCrossRefGoogle Scholar
  7. 7.
    C. Czerkinsky, L. Nilsson, H. Nygren, O. Ouchterlony, and A. Tarkowski, J. Immunol. Methods 65: 109 (1983).PubMedCrossRefGoogle Scholar
  8. 8.
    S. S. Ogra and P. L. Ogra, J. Pediatr. 92: 550 (1978).PubMedCrossRefGoogle Scholar
  9. 9.
    I. Moro, T. Abo, S. S. Crago, K. Komiyama, and J. Mestecky, Cell. Immunol. 93: 467 (1985).PubMedCrossRefGoogle Scholar
  10. 10.
    J. Clemente, N. Clerizi, M. Espinosa, and F. Leyva-Cobian, Immunol. Lett. 12: 271 (1986).PubMedCrossRefGoogle Scholar
  11. 11.
    W. Pittard and K. Bill, Cell. Immunol. 42: 437 (1977).CrossRefGoogle Scholar
  12. 12.
    H. Shinmoto, H. Kawakami, S. Dosako, and Y. Sogo, Clin. Exp. Immunol. 66: 223 (1986).PubMedGoogle Scholar
  13. 13.
    S. Roberts and D. Freed, Lancet ii: 1131 (1977).Google Scholar
  14. 14.
    S. Gross and R. Buckley, Lancet ii: 543 (1980).Google Scholar
  15. 15.
    S. Stephens, Arch. Dis. Child. 61: 263 (1986).PubMedCrossRefGoogle Scholar
  16. 16.
    A. Prentice, Arch. Dis. Child. 62: 792 (1987).PubMedCrossRefGoogle Scholar
  17. 17.
    W. Lerchardt, H. Karashuyama, A. Rolink, and F. Melchers, Immunol. Rev. 99: 241 (1987).CrossRefGoogle Scholar
  18. 18.
    C. Snapper, C. Peschel, and W. Paul, J. Immunol. 140: 2121 (1988).PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Igor I. Slukvin
    • 1
  • Valentina V. Pilipenko
    • 1
  • Victor P. Chernyshov
    • 1
  • Alexey A. Philchenkov
    • 2
  1. 1.Laboratory of ImmunologyUkrainian Institute of Pediatrics, Obstetrics and GynecologyKievUkraine
  2. 2.Institute for Oncology and Radiology ProblemsKievUkraine

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