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In Vivo Switching: Identification of Germline Transcripts For Human IgA

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Advances in Mucosal Immunology

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 371))

Abstract

Transforming growth factor β1 (TGF-β1) induces the earliest known steps of isotype switching to IgA in humans. Switching is preceded by transcription of ‘I-exons’ located 5’ of the Ig switch regions. Such mRNA species lack a variable portion and are denoted ‘germline’ transcripts. We have previously identified I-regions and we have now investigated the in vivo expression of human germline transcripts. Decreased levels of germline a transcripts (containing an lα exon) were found in Ig deficiency diseases and in IgA nephropathy. These findings are compatible with an in vivo role of germline transcription in isotype switching and may contribute to the understanding of mechanisms underlaying abnormalities in the immune system.

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Authors and Affiliations

  1. Department of Clinical Immunology, Center for Biotechnology, Karolinska Institute at Novum, S-141 57, Huddinge, Sweden

    C. I. E. Smith, B. Baskin, L. Hammarstrom & K. B. Islam

  2. Department of Nephrology, Karolinska Institute at Huddinge Hospital, S-141 86, Huddinge, Sweden

    E. Pattersson

Authors
  1. C. I. E. Smith
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  2. B. Baskin
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  3. E. Pattersson
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  4. L. Hammarstrom
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  5. K. B. Islam
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Editor information

Editors and Affiliations

  1. University of Alabama at Birmingham, Birmingham, Alabama, USA

    Jiri Mestecky , Michael W. Russell , Susan Jackson  & Suzanne M. Michalek , ,  & 

  2. Academy of Sciences of the Czech Republic, Prague, Czech Republic

    Helena Tlaskalová-Hogenová  & Jaroslav Šterzl  & 

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© 1995 Springer Science+Business Media New York

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Smith, C.I.E., Baskin, B., Pattersson, E., Hammarstrom, L., Islam, K.B. (1995). In Vivo Switching: Identification of Germline Transcripts For Human IgA. In: Mestecky, J., Russell, M.W., Jackson, S., Michalek, S.M., Tlaskalová-Hogenová, H., Šterzl, J. (eds) Advances in Mucosal Immunology. Advances in Experimental Medicine and Biology, vol 371. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1941-6_2

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  • DOI: https://doi.org/10.1007/978-1-4615-1941-6_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5796-4

  • Online ISBN: 978-1-4615-1941-6

  • eBook Packages: Springer Book Archive

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