Opsono-Phagocytosis of Non-Encapsulated Haemophilus Influenzae

  • Liesbeth Vogel
  • Loek van Alphen
  • Forien Geluk
  • Henk Jansen
  • Jacob Dankert
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 371)


Non-encapsulated Haemophilus influenzae causes serious respiratory tract infections in adults with chronic obstructive pulmonary disease (COPD).1 These bacteria persist despite the presence of abundant numbers of polymorphonuclear leukocytes (PMNs), complement, and antibodies specific for the infecting organism in the sputum.1,2,3,4 Opsono-phagocytosis, an important immune defense mechanism toeliminate bacterial intruders3, is also operating in the bronchial tree. The basic mechanisms for persistence of H.influenzae in the bronchial tree are unknown, buthost and bacterial factors are likely to contribute1,5,6, one of them might be adisturbed opsono-phagocytosis.


Chronic Obstructive Pulmonary Disease Chronic Obstructive Pulmonary Disease Patient Polymorphonuclear Leukocyte Colony Counting Bronchial Tree 
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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Liesbeth Vogel
    • 1
  • Loek van Alphen
    • 1
  • Forien Geluk
    • 1
  • Henk Jansen
    • 2
  • Jacob Dankert
    • 1
  1. 1.Departments of Medical MicrobiologyUniversity of AmsterdamAmsterdamThe Netherlands
  2. 2.Departments of PulmonologyAcademic Medical CenterAmsterdamThe Netherlands

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