The Binding of Monomeric IgA to Myeloid FcαR: Evidence for Receptor Re-Cycling and Determination of its Affinity

  • Wilson W. Stewart
  • Michael A. Kerr
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 371)

Abstract

Receptors for the Fc region of immunoglobulins (FcRs) have been identified on a variety of cell types and have been shown to promote multiple cellular functions.1,2 They are differentially expressed on different types of leucocyte and show slightly different subclass specificity.3 Only FcγRI binds to monomeric IgG with sufficient affinity that binding is likely to occur at physiological concentrations. Efficient binding of IgG to FcγRII and FcγRIII only occurs when the IgG is aggregated. Binding of aggregated IgG causes clustering of Fc receptors which triggers a biological response by the cell.

Keywords

Filtration Carbohydrate Superoxide 

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References

  1. 1.
    I. Mellman, Curr. Opin. Immunol. 1: 16 (1988).PubMedCrossRefGoogle Scholar
  2. 2.
    M. W. Fanger, L. Shen, R. F. Graziano, and P. M. Guyre, Immunology Today 10: 92 (1989).PubMedCrossRefGoogle Scholar
  3. 3.
    J. G. J. Van de Winkel and C. L. Anderson, J. Leuk. Biol 49: 511 (1991).Google Scholar
  4. 4.
    M. A. Kerr, Biochem. J. 271: 285 (1990).PubMedGoogle Scholar
  5. 5.
    A. Gorter, P. S. Hiemstra, P. C. J. Leijh, M. E. Van Der Sluys, M. T. Van Den Barselaar, L. A. Van Es, and M. R. Daha, Immunology 61: 303 (1987).PubMedGoogle Scholar
  6. 6.
    G. R. Yeaman and M. A. Kerr, Clin. Exp. Immunol 68: 200 (1987).PubMedGoogle Scholar
  7. 7.
    W. W. Stewart and M. A. Kerr, Immunology 71: 328 (1990).PubMedGoogle Scholar
  8. 8.
    L. Shen and J. Collins, Immunology 68: 491 (1989).PubMedGoogle Scholar
  9. 9.
    M. W. Fanger, S. N. Goldstine, and L. Shen, Ann. N. Y. Acad. Sci. 409 (2): 552 (1983).PubMedCrossRefGoogle Scholar
  10. 10.
    R. C. Monteiro, H. Kubagawa, and M. D. Cooper, J. Exp. Med. 171: 597 (1990).PubMedCrossRefGoogle Scholar
  11. 11.
    M. Albrechtsen, G. R. Yeaman, and M. A. Kerr, Immunology 64: 201 (1988).PubMedGoogle Scholar
  12. 12.
    R. L. Mazengera and M. A. Kerr, Biochem. J. 272: 159 (1990).PubMedGoogle Scholar
  13. 13.
    L. Shen, J. Leuk. Biol 51: 373 (1992).Google Scholar

Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Wilson W. Stewart
    • 1
  • Michael A. Kerr
    • 1
  1. 1.Department of PathologyUniversity of Dundee, Ninewells Hospital Medical SchoolDundeeScotland

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