The Binding of Monomeric IgA to Myeloid FcαR: Evidence for Receptor Re-Cycling and Determination of its Affinity

  • Wilson W. Stewart
  • Michael A. Kerr
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 371)


Receptors for the Fc region of immunoglobulins (FcRs) have been identified on a variety of cell types and have been shown to promote multiple cellular functions.1,2 They are differentially expressed on different types of leucocyte and show slightly different subclass specificity.3 Only FcγRI binds to monomeric IgG with sufficient affinity that binding is likely to occur at physiological concentrations. Efficient binding of IgG to FcγRII and FcγRIII only occurs when the IgG is aggregated. Binding of aggregated IgG causes clustering of Fc receptors which triggers a biological response by the cell.


Respiratory Burst IgAl Fraction Sufficient Affinity Chain Antiserum Dimer IgAl 
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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Wilson W. Stewart
    • 1
  • Michael A. Kerr
    • 1
  1. 1.Department of PathologyUniversity of Dundee, Ninewells Hospital Medical SchoolDundeeScotland

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