Effects of Electrotonic Spread of EPSPs on Synaptic Transmission in Motoneurones: A Simulation Study
Distal synaptic inputs to motoneurones produce Post Synaptic Potentials (PSP) at the soma with longer rise times and half widths than proximal inputs. This is due to electrotonic spread of the PSP. Previous studies have concentrated on the time course of a single compound EPSP at the soma for a variety of pre-synaptic input configurations (e.g. Segev, Fleshman & Burke, 1990). The EPSP represents only an intermediate variable in determining the output discharge of a cell. Simulation studies with compartmental models of motoneurones were used to investigate the functional consequences of synaptic location on synaptic transmission during repetitive firing.
KeywordsSpike Train Repetitive Firing Post Synaptic Potential Synaptic Location Coherence Estimate
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