Abstract
Formation of muscle spindles in hindlimbs of rodents is dependent on contact between a sensory neurone and a developing muscle fibre (Zelená, 1957). This type of contact not only induces the formation of intrafusal fibres, but may also mediate the support of proprioceptive neurones in the dorsal root ganglia (DRGs) by muscle-derived trophic factors. Neurotrophins such as brain-derived neurotrophic factor (BDNF) or neurotrophin-3 (NT-3) support the survival of developing muscle sensory neurones in-vitro and can be retrogradely transported to DRGs from muscles (DiStephano, Friedman, Radziejewski, Alexander, Boland, Schick, Lindsay & Wiegand, 1992; Hory-Lee, Russell, Lindsay & Frank, 1993). Subpopulations of DRG neurones express the BDNF and NT-3 receptors, trkB and trkC (Mu, Silos-Santiago, Carroll & Snider, 1993).
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References
Distephano, P. S., Friedman, B., Radziejewski, C, Alexander, C., Boland, P., Schick, C. M., Lindsay, R. & Wiegand, S. J. (1992) The neurotrophins BDNF, NT-3 and NGF display distinct patterns of retrograde axonal transport in peripheral and central neurons. Neuron 981-993.
Ernfors, P., Lee, K.-F., Kucera, J. & Jaenisch, R. (1994a) Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents. Cell 77, 503–512.
Ernfors, P., Lee, K.-F. & Jaenisch, R. (1994b) Mice lacking brain-derived neurotrophic factor develop with sensory deficits. Nature 368, 147–150.
Hory-Lee, F., Russell, M., Lindsay, R. M. & Frank, E. (1993) Neurotrophin-3 supports the survival of developing muscle sensory neurons in culture. Proc. Natl. Acad. Sci. USA 90, 2613–2617.
Kelly, A. M. & Zacks, S. I. (1969) The histogenesis of rat intercostal muscle. J. Cell Biol. 42, 152–435.
Klein, R., Silos-Santiago, I., Smeyne, R.J., Lira, S. A., Brambilla, R., Bryant, S., Zhang, L., Snider, W. D. & Barbacid, M. (1994) Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements. Nature 368, 249–251.
Kucera, J. & Walro, J. M. (1992) Superfluousness of motor innervation for the formation of muscle spindles in neonatal rats. Anat. Embryol. 186, 301–309.
Kucera, J., Walro, J. M., Gao, Y. (1993) Fusimotor-free spindles in reinnervated muscles of neonatal rats. Neuroscience 52, 219–228.
Mu, X., Silos-Santiago, I., Carroll, S. L. & Snider, W. D. (1993) Neurotrophin receptor genes are expressed in distinct patterns in developing dorsal root ganglia. J. Neurosci. 13, 4029–4041.
Rambourg, A., Clermont, Y. & Beaudet, A. (1983) Ultrastructural features of six types of neurons in rat dorsal root ganglia. J. Neurocytol. 12, 47–66.
Zelená, J. (1957) The morphogenetic influence of innervation on the ontogenic development of muscle-spindles. J. Embryol. Exp. Morphol. 5, 283–292.
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© 1995 Springer Science+Business Media New York
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Kucera, J., Ernfors, P., Schwarze, J., Jaenisch, R. (1995). Early Development of the Muscle Spindle and its Dependence on Neurotrophic Factors. In: Taylor, A., Gladden, M.H., Durbaba, R. (eds) Alpha and Gamma Motor Systems. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1935-5_39
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DOI: https://doi.org/10.1007/978-1-4615-1935-5_39
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