Muscle Perfusion and Control of Breathing
When metabolic rate varies, as in exertion, respiratory homeostasis relies on the ventilatory as well as the cardiovascular system in order to match pulmonary and tissue gas exchange rates. It has been consistently demonstrated that the dynamics and magnitude of ventilation can be dramatically reduced in humans and animals when the limb blood flow is impeded during the recovery from (1, 3, 4, 5, 6), as well as at the onset of a muscular exercise (5), with little change in PaCO2. A mechanism has been recently suggested to explain the above observations, that is, changing blood flow in the muscles affects ventilation (5). In other words, a perfusion-linked stimulus to ventilation could originate in the muscular circulation or its immediate vicinity, coupling ventilation to the degree of muscle hyperaemia.
KeywordsVentilatory Response Femoral Nerve Afferent Fibre Arterial Inflow Muscle Perfusion
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- 1.Dejours, P., 1964, Control of respiration in muscular exercise, Handbook of Physiology. Respiration, sect. 3, vol. I, chapt. 25:631–648.Google Scholar
- 2.Enders, A., and Schmidt L., 1962. Der Andgriffspunkt der atmungsanregenden wirkung des papaverins. Arch Int. Pharmacodyn. 91:157.Google Scholar
- 4.Haouzi, P., Huszczuk A., Gille J.P., Chalon B., Marchal F., Crance J.P., and Whipp B.J.,1995, Vascular distension in muscle contributes to respiratory control in sheep. Respir. Physiol. In press.Google Scholar
- 9.Mitchell, J.H, and Schmitt R.F.,1983, Cardiovascular reflex control by afferent fibers from skeletal muscle receptors. In: Handbook of Physiology. The cardiovascular System., Bethesda, M.D.: American Physiological Society, Sect. 2, Vol. III, Chapt. 17, p. 623–637.Google Scholar
- 10.Nims, R.G., Severinghaus LW., and Comroe J.H.,1953, Reflexe hyperpnea induced by papaver ne acting upon the carotid and aortic bodies. J. Pharmacol. Exptl. Therap. 109: 58–61.Google Scholar
- 12.Oren, A., Huszczuk A., Pokorski M., Ferrer P.H., Whipp B.J., and Wasserman K.,1983, Evidence for a peripheral vascular origin of the isoproterenol induced hyperpnea in the dog. The Physiologist 26: A-95.Google Scholar
- 13.Paintal, A.S., 1960, Functional analysis of group III afferent fibers of mammalian muscles. J. Physiol. (London). 152: 250–270.Google Scholar