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Modeling and Control of Ventilation pp 257–260Cite as

Hypoxic Ventilatory Depression May be Due to Central Chemoreceptor Cell Hyperpolarization

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 393))

Abstract

This paper concerns the possible relationship of the acid secretion found to be localized primarily over the medullary ventral surface CO2 chemosensitive regions to the phenomenon of hypoxic ventilatory depression, HVD, or “roll-off”. HVD occurs between the 5th and 25th minutes of acute steady isocapnic hypoxia in normal man at sea level, eliminating about half of the hypoxic ventilatory stimulus without reducing the slope of the CO2 response curve or central response to a constant stimulus from peripheral chemoreceptors [1–4], recovery requiring similar times [5]. We have demonstrated hypoxic ventilatory depression (HVD) of subjects breathing ambient air, with SaO2-80–90% [6,7]. After 25 min at SpO2 = 75%, when ventilation was apparently depressed by HVD, subjects had normal or above-normal HVR (computed as the differential slope) when SpO2 was rapidly lowered from 75% to 65%.

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Authors and Affiliations

  1. Department of Anesthesia and Cardiovascular Research Institute, University of California, San Francisco, Box 0542, California, USA

    John W. Severinghaus

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  1. John W. Severinghaus
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Editor information

Editors and Affiliations

  1. Charing Cross and Westminster Medical School, London, England

    Stephen J. G. Semple  & Lewis Adams  & 

  2. St. George’s Hospital Medical School, London, England

    Brian J. Whipp

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© 1995 Springer Science+Business Media New York

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Severinghaus, J.W. (1995). Hypoxic Ventilatory Depression May be Due to Central Chemoreceptor Cell Hyperpolarization. In: Semple, S.J.G., Adams, L., Whipp, B.J. (eds) Modeling and Control of Ventilation. Advances in Experimental Medicine and Biology, vol 393. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1933-1_48

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  • DOI: https://doi.org/10.1007/978-1-4615-1933-1_48

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5792-6

  • Online ISBN: 978-1-4615-1933-1

  • eBook Packages: Springer Book Archive

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