Abstract
A fascinating question in developmental biology is how different regions of the animal embryo are specified. In particular, the uncovering of the molecular rules governing head development, has been the focus of studies by investigators working in a wide range of developmental systems.
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References
Bulfone A, Puelles L, Porteus MH, Frohman MA, Martin GR and Rubenstein JLR (1993): Spatially restricted expression of Dlx-1, Dlx-2 (Tes-1), Gbx-2 and Wnt-3 in the embryonic day 12.5 mouse forebrain defines potential transverse and longitudinal segmental boundaries. J Neurosci 13: 3155–3172.
Bally-Cuif L, Gulisano M, Broccoli V and Boncinelli E (1994): c-otx2 is expressed in two different phases of gastrulation and is sensitive to retinoic acid treatment in chick embryo. Mech Dev (in press).
Blum M, Gaunt SJ, Cho KWY, Steinbeisser H, Blumberg B, Bittner D and De Robertis EM (1992): Gastrulation in the mouse: the role of the homeobox gene goosecoid. Cell 69: 1097–1106
Blumberg B, Wright CVE, De Robertis EM and Cho KWY (1991): Organizer-specific homeobox genes in Xenopus laevis embryo. Science 253: 194–196
Boncinelli E, Simeone A, Acampora D, Mavilio F (1991) HOX gene activation by retinoic acid. Trends Genet 7: 329–334
Boncinelli E, Gulisano M and Broccoli V (1993): Emx and Otx homeobox genes in the developing mouse brain. J. Neurobiology 24: 1356–1366
Boncinelli E (1994): Early CNS development: Distal-less related genes and forebrain development. Current.Opinion. in Neurobiology 4: 29–36
Capovilla M, Brandt M and Botas J (1994): Direct regulation of decapentaplegic by Ultrabithorax and its role in Drosophila midgut morphogenesis. Cell 76: 461–475
Cohen S and Jürgens G (1991): Drosophila headlines. Trends Genet 7: 267–272
Dalton D, Chadwick R and McGinnis W (1989): Expression and embryonic function of empty spiracles: a Drosophila homeobox gene with two patterning functions on the anterior-posterior axis of the embryo. Genes Dev 3: 1940–1956
Driever W and Nüsslein-Volhard C (1988): The bicoid protein determines position in the Drosophila embryo in a concentration-dependent manner. Cell 54: 95–104
Figdor M and Stern C (1993): Segmental organization of embryonic diencephalon. Nature 363, 630–634.
Finkelstein R, Smouse D, Capaci T, Spradling AC and Perrimon, N (1990): The orthodenticle gene encodes a novel homeo domain protein involved in the development of the Drosophila nervous system and ocellar visual structures. Genes Dev 4: 1516–1527
Finkelstein R and Perrimon N (1991): The molecular genetics of head development in Drosophila melanogaster. Development 112: 899–912
Frantz GD, Weimann JM, Levin ME and McConnell SK (1994): Otxl and Otx2 define layers and regions in developing cerebral cortex. J Neurosci 14: 5725–5740.
Frohman MA, Boyle M and Martin GR (1990): Isolation of the mouse Hox-2.9 gene; analysis of embryonic expression suggests that positional information along the anterior-posterior axis is specified by mesoderm. Development 110: 589–607
Gehring WJ, Qiu Qian Y, Billeter M, Furukubo-Tokunaga K, Schier AF, Resendez-Perez D, Affolter M, Offing G and Wutrich K (1994): Homeodomain-DNA recognition. Cell 78: 211–223.
Guazzi S, Lonigro R, Pintonello L, Boncinelli E, Di Lauro R and Mavilio F (1994): The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins. EMBO J 13: 3339–3347
Hoppler S and Bienz M (1994): Specification of a single cell type by a Drosophila homeotic gene. Cell 76: 689–702
Hunt P, Gulisano M, Cook M, Sham M-H, Faiella A, Wilkinson D, Boncinelli E and Krumlauf R (1991): A distinct Hox code for the branchial region of the vertebrate head. Nature 353: 861–864.
Izpisua-Belmonte JC, De Robertis EM, Storey KG and Stern CD (1993): The homeobox gene goosecoid and the origin of organizer cells in the early chick blastoderm. Cell 74: 645–659
Jones B and McGinnis W (1993): The regulation of empty spiracles by Abdominal-B mediates an abdominal segment identity function. Genes Dev 7: 229–240
Kastury K, Druck T, Huebner K, Barletta C, Acampora D, Simeone A, Faiella A and Boncinelli E (1994): Chromosome locations of human EMX and OTX genes. Genomics 22: 41–45
Kessel M and Gruss P (1991): Homeotic transformations of murine vertebrae and concomitant alteration of Hox codes induced by retinoic acid. Cell 67: 89–104
Krumlauf R (1994): Hox genes in vertebrate development Cell 78: 191–201
Kuhlenbeck H (1973): “The Central Nervous System of Vertebrates. Vol. 3 Part II. Overall morphologic pattern”. Basel: Karger.
Lawson KA, Meneses JJ and Pedersen RA (1991): Clonal analysis of epiblast fate during germ layer formation in the mouse embryo. Development 113: 891–911
Levine M and Hoey T (1988): Homeobox proteins as sequence specific transcription factors. Cell 55: 537–540
Luskin MB, Pearlman AL and Sanes JR (1988): Cell lineage in the cerebral cortex of the mouse studied in vivo and in vitro with a recombinant retrovirus. Neuron 1: 635–647
Martinez S, Wassef M and Alvarado-Mallard RM (1991): Induction of a mesencephalic phenotype in the 2-day-old chick prosencephalon is preceded by the early expression of the homeobox gene en. Neuron 6: 971–981
McGinnis W and Krumlauf R (1992): Homeobox genes and axial patterning. Cell 68: 283–302.
Pannese M, Polo C, Andreazzoli M, Vignali R, Kablar B, Barsacchi G and Boncinelli E (1995): The Xenopus homologue of Otx2 is a maternal homeobox gene that demarcates and specifies anterior strctures in frog embryos. Development (in press).
Price M, Lemaistre M, Pischetola M, Di Lauro R and Duboule D (1991): A mouse gene related to distal-less shows a restricted expression in the developing forebrain. Nature 351: 748–751.
Price M, Lazzaro D, Pohl T, Mattei M-G, Rüther U, Olivo J-C, Duboule D and Di Lauro R (1992): Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain. Neuron 8: 241–255.
Porteus MH, Bulfone A, Ciaranello RD and Rubenstein JLR (1991): Isolation and characterization of a novel cDNA clone encoding a homeodomain that is developmentally regulated in the ventral forebrain. Neuron 7: 221–229.
Puelles L, Amat JA and Martinez-de-la-Torre M (1987): Segment-related, mosaic neurogenetic pattern in the forebrain and mesencephalon of early chick embryos: I. Topography of AchE-positive neuroblasts up to stage HH18. J Comp Neurol 266: 247–268.
Robinson GW, Wray S and Mahon, KA (1991): Spatially restricted expression of a member of a new family of murine distal-less homeobox genes in the developing forebrain. New Biologist 3: 1183–1194.
Sakai Y (1987): Neurulation in the mouse I. The ontogenesis of neural segments and the determination of topographical regions in a central nervous system. Anat Rec 218: 450–457
Salinas PC and Nusse R (1992): Regional expression of the Wnt-3 gene in the developing mouse forebrain in relationship to diencephalic neuromeres. Mech Dev 39: 1511–60.
Simeone A, Acampora D, Gulisano M, Stornaiuolo A and Boncinelli E (1992a): Nested expression domains of four homeobox genes in developing rostral brain. Nature 358: 687–690.
Simeone A, Gulisano M, Acampora D, Stornaiuolo A, Rambaldi M and Boncinelli E (1992b): Two vertebrate homeobox genes related to the Drosophila empty spiracles gene are expressed in the embryonic cerebral cortex. embo j 11: 2541–2550.
Simeone A, Acampora D, Mallamaci A, Stornaiuolo A, D’Apice M R, Nigro V and Boncinelli, E (1993): A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo. Embo J 12: 2735–2747
Simeone A, Acampora D, Pannese M, D’Esposito M, Stornaiuolo A, Gulisano M, Mallamaci A, Kastury K, Druck T, Huebner K and Boncinelli E (1993): Cloning and characterization of two new members of the vertebrate dlx gene family. Proc Natl Acad Sci USA 91: 2250–2254.
Tam PPL (1989): Regionalisation of the mouse embryonic ectoderm: allocation of prospective ectodermal tissues during gastrulation. Development 107: 55–67
Tessier-Lavigne M (1992): Axon guidance by molecular gradients. Curr Opinion Neurobiol 2: 60–65.
Walldorf U and Gehring WJ (1992): empty spiracles, a gap gene containing a homeobox involved in Drosophila head development. EMBO J 11: 2247–2259
Wieschaus E, Perrimon N and Finkelstein R (1992): orthodenticle activity is required for development of medial structures in the larval and adult epidermis of Drosophila. Development 115: 801–811
Wilkinson DG, Bhatt S, Cook M, Boncinelli E and Krumlauf R (1989): Segmental expression of Hox-2 homeobox-containing genes in the developing mouse hindbrain. Nature 341: 405–409
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Gulisano, M., Broccoli, V., Spada, F., Boncinelli, E. (1995). Potential Role of Homeobox Genes in Neural Cell Differentiation. In: Juurlink, B.H.J., Krone, P.H., Kulyk, W.M., Verge, V.M.K., Doucette, J.R. (eds) Neural Cell Specification. Altschul Symposia Series, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1929-4_5
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DOI: https://doi.org/10.1007/978-1-4615-1929-4_5
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