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Potential Role of Homeobox Genes in Neural Cell Differentiation

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Neural Cell Specification

Part of the book series: Altschul Symposia Series ((ALSS,volume 3))

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Abstract

A fascinating question in developmental biology is how different regions of the animal embryo are specified. In particular, the uncovering of the molecular rules governing head development, has been the focus of studies by investigators working in a wide range of developmental systems.

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References

  • Bulfone A, Puelles L, Porteus MH, Frohman MA, Martin GR and Rubenstein JLR (1993): Spatially restricted expression of Dlx-1, Dlx-2 (Tes-1), Gbx-2 and Wnt-3 in the embryonic day 12.5 mouse forebrain defines potential transverse and longitudinal segmental boundaries. J Neurosci 13: 3155–3172.

    PubMed  CAS  Google Scholar 

  • Bally-Cuif L, Gulisano M, Broccoli V and Boncinelli E (1994): c-otx2 is expressed in two different phases of gastrulation and is sensitive to retinoic acid treatment in chick embryo. Mech Dev (in press).

    Google Scholar 

  • Blum M, Gaunt SJ, Cho KWY, Steinbeisser H, Blumberg B, Bittner D and De Robertis EM (1992): Gastrulation in the mouse: the role of the homeobox gene goosecoid. Cell 69: 1097–1106

    Article  PubMed  CAS  Google Scholar 

  • Blumberg B, Wright CVE, De Robertis EM and Cho KWY (1991): Organizer-specific homeobox genes in Xenopus laevis embryo. Science 253: 194–196

    Article  PubMed  CAS  Google Scholar 

  • Boncinelli E, Simeone A, Acampora D, Mavilio F (1991) HOX gene activation by retinoic acid. Trends Genet 7: 329–334

    PubMed  CAS  Google Scholar 

  • Boncinelli E, Gulisano M and Broccoli V (1993): Emx and Otx homeobox genes in the developing mouse brain. J. Neurobiology 24: 1356–1366

    Article  CAS  Google Scholar 

  • Boncinelli E (1994): Early CNS development: Distal-less related genes and forebrain development. Current.Opinion. in Neurobiology 4: 29–36

    Article  PubMed  CAS  Google Scholar 

  • Capovilla M, Brandt M and Botas J (1994): Direct regulation of decapentaplegic by Ultrabithorax and its role in Drosophila midgut morphogenesis. Cell 76: 461–475

    Article  PubMed  CAS  Google Scholar 

  • Cohen S and Jürgens G (1991): Drosophila headlines. Trends Genet 7: 267–272

    PubMed  CAS  Google Scholar 

  • Dalton D, Chadwick R and McGinnis W (1989): Expression and embryonic function of empty spiracles: a Drosophila homeobox gene with two patterning functions on the anterior-posterior axis of the embryo. Genes Dev 3: 1940–1956

    Article  PubMed  CAS  Google Scholar 

  • Driever W and Nüsslein-Volhard C (1988): The bicoid protein determines position in the Drosophila embryo in a concentration-dependent manner. Cell 54: 95–104

    Article  PubMed  CAS  Google Scholar 

  • Figdor M and Stern C (1993): Segmental organization of embryonic diencephalon. Nature 363, 630–634.

    Article  PubMed  CAS  Google Scholar 

  • Finkelstein R, Smouse D, Capaci T, Spradling AC and Perrimon, N (1990): The orthodenticle gene encodes a novel homeo domain protein involved in the development of the Drosophila nervous system and ocellar visual structures. Genes Dev 4: 1516–1527

    Article  PubMed  CAS  Google Scholar 

  • Finkelstein R and Perrimon N (1991): The molecular genetics of head development in Drosophila melanogaster. Development 112: 899–912

    PubMed  CAS  Google Scholar 

  • Frantz GD, Weimann JM, Levin ME and McConnell SK (1994): Otxl and Otx2 define layers and regions in developing cerebral cortex. J Neurosci 14: 5725–5740.

    PubMed  CAS  Google Scholar 

  • Frohman MA, Boyle M and Martin GR (1990): Isolation of the mouse Hox-2.9 gene; analysis of embryonic expression suggests that positional information along the anterior-posterior axis is specified by mesoderm. Development 110: 589–607

    PubMed  CAS  Google Scholar 

  • Gehring WJ, Qiu Qian Y, Billeter M, Furukubo-Tokunaga K, Schier AF, Resendez-Perez D, Affolter M, Offing G and Wutrich K (1994): Homeodomain-DNA recognition. Cell 78: 211–223.

    Article  PubMed  CAS  Google Scholar 

  • Guazzi S, Lonigro R, Pintonello L, Boncinelli E, Di Lauro R and Mavilio F (1994): The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins. EMBO J 13: 3339–3347

    PubMed  CAS  Google Scholar 

  • Hoppler S and Bienz M (1994): Specification of a single cell type by a Drosophila homeotic gene. Cell 76: 689–702

    Article  PubMed  CAS  Google Scholar 

  • Hunt P, Gulisano M, Cook M, Sham M-H, Faiella A, Wilkinson D, Boncinelli E and Krumlauf R (1991): A distinct Hox code for the branchial region of the vertebrate head. Nature 353: 861–864.

    Article  PubMed  CAS  Google Scholar 

  • Izpisua-Belmonte JC, De Robertis EM, Storey KG and Stern CD (1993): The homeobox gene goosecoid and the origin of organizer cells in the early chick blastoderm. Cell 74: 645–659

    Article  PubMed  CAS  Google Scholar 

  • Jones B and McGinnis W (1993): The regulation of empty spiracles by Abdominal-B mediates an abdominal segment identity function. Genes Dev 7: 229–240

    Article  PubMed  CAS  Google Scholar 

  • Kastury K, Druck T, Huebner K, Barletta C, Acampora D, Simeone A, Faiella A and Boncinelli E (1994): Chromosome locations of human EMX and OTX genes. Genomics 22: 41–45

    Article  PubMed  CAS  Google Scholar 

  • Kessel M and Gruss P (1991): Homeotic transformations of murine vertebrae and concomitant alteration of Hox codes induced by retinoic acid. Cell 67: 89–104

    Article  PubMed  CAS  Google Scholar 

  • Krumlauf R (1994): Hox genes in vertebrate development Cell 78: 191–201

    Article  PubMed  CAS  Google Scholar 

  • Kuhlenbeck H (1973): “The Central Nervous System of Vertebrates. Vol. 3 Part II. Overall morphologic pattern”. Basel: Karger.

    Google Scholar 

  • Lawson KA, Meneses JJ and Pedersen RA (1991): Clonal analysis of epiblast fate during germ layer formation in the mouse embryo. Development 113: 891–911

    PubMed  CAS  Google Scholar 

  • Levine M and Hoey T (1988): Homeobox proteins as sequence specific transcription factors. Cell 55: 537–540

    Article  PubMed  CAS  Google Scholar 

  • Luskin MB, Pearlman AL and Sanes JR (1988): Cell lineage in the cerebral cortex of the mouse studied in vivo and in vitro with a recombinant retrovirus. Neuron 1: 635–647

    Article  PubMed  CAS  Google Scholar 

  • Martinez S, Wassef M and Alvarado-Mallard RM (1991): Induction of a mesencephalic phenotype in the 2-day-old chick prosencephalon is preceded by the early expression of the homeobox gene en. Neuron 6: 971–981

    Article  PubMed  CAS  Google Scholar 

  • McGinnis W and Krumlauf R (1992): Homeobox genes and axial patterning. Cell 68: 283–302.

    Article  PubMed  CAS  Google Scholar 

  • Pannese M, Polo C, Andreazzoli M, Vignali R, Kablar B, Barsacchi G and Boncinelli E (1995): The Xenopus homologue of Otx2 is a maternal homeobox gene that demarcates and specifies anterior strctures in frog embryos. Development (in press).

    Chapter  Google Scholar 

  • Price M, Lemaistre M, Pischetola M, Di Lauro R and Duboule D (1991): A mouse gene related to distal-less shows a restricted expression in the developing forebrain. Nature 351: 748–751.

    Article  PubMed  CAS  Google Scholar 

  • Price M, Lazzaro D, Pohl T, Mattei M-G, Rüther U, Olivo J-C, Duboule D and Di Lauro R (1992): Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain. Neuron 8: 241–255.

    Article  PubMed  CAS  Google Scholar 

  • Porteus MH, Bulfone A, Ciaranello RD and Rubenstein JLR (1991): Isolation and characterization of a novel cDNA clone encoding a homeodomain that is developmentally regulated in the ventral forebrain. Neuron 7: 221–229.

    Article  PubMed  CAS  Google Scholar 

  • Puelles L, Amat JA and Martinez-de-la-Torre M (1987): Segment-related, mosaic neurogenetic pattern in the forebrain and mesencephalon of early chick embryos: I. Topography of AchE-positive neuroblasts up to stage HH18. J Comp Neurol 266: 247–268.

    Article  PubMed  CAS  Google Scholar 

  • Robinson GW, Wray S and Mahon, KA (1991): Spatially restricted expression of a member of a new family of murine distal-less homeobox genes in the developing forebrain. New Biologist 3: 1183–1194.

    PubMed  CAS  Google Scholar 

  • Sakai Y (1987): Neurulation in the mouse I. The ontogenesis of neural segments and the determination of topographical regions in a central nervous system. Anat Rec 218: 450–457

    Article  PubMed  CAS  Google Scholar 

  • Salinas PC and Nusse R (1992): Regional expression of the Wnt-3 gene in the developing mouse forebrain in relationship to diencephalic neuromeres. Mech Dev 39: 1511–60.

    Article  Google Scholar 

  • Simeone A, Acampora D, Gulisano M, Stornaiuolo A and Boncinelli E (1992a): Nested expression domains of four homeobox genes in developing rostral brain. Nature 358: 687–690.

    Article  CAS  Google Scholar 

  • Simeone A, Gulisano M, Acampora D, Stornaiuolo A, Rambaldi M and Boncinelli E (1992b): Two vertebrate homeobox genes related to the Drosophila empty spiracles gene are expressed in the embryonic cerebral cortex. embo j 11: 2541–2550.

    CAS  Google Scholar 

  • Simeone A, Acampora D, Mallamaci A, Stornaiuolo A, D’Apice M R, Nigro V and Boncinelli, E (1993): A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo. Embo J 12: 2735–2747

    PubMed  CAS  Google Scholar 

  • Simeone A, Acampora D, Pannese M, D’Esposito M, Stornaiuolo A, Gulisano M, Mallamaci A, Kastury K, Druck T, Huebner K and Boncinelli E (1993): Cloning and characterization of two new members of the vertebrate dlx gene family. Proc Natl Acad Sci USA 91: 2250–2254.

    Article  Google Scholar 

  • Tam PPL (1989): Regionalisation of the mouse embryonic ectoderm: allocation of prospective ectodermal tissues during gastrulation. Development 107: 55–67

    PubMed  CAS  Google Scholar 

  • Tessier-Lavigne M (1992): Axon guidance by molecular gradients. Curr Opinion Neurobiol 2: 60–65.

    Article  CAS  Google Scholar 

  • Walldorf U and Gehring WJ (1992): empty spiracles, a gap gene containing a homeobox involved in Drosophila head development. EMBO J 11: 2247–2259

    PubMed  CAS  Google Scholar 

  • Wieschaus E, Perrimon N and Finkelstein R (1992): orthodenticle activity is required for development of medial structures in the larval and adult epidermis of Drosophila. Development 115: 801–811

    PubMed  CAS  Google Scholar 

  • Wilkinson DG, Bhatt S, Cook M, Boncinelli E and Krumlauf R (1989): Segmental expression of Hox-2 homeobox-containing genes in the developing mouse hindbrain. Nature 341: 405–409

    Article  PubMed  CAS  Google Scholar 

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Gulisano, M., Broccoli, V., Spada, F., Boncinelli, E. (1995). Potential Role of Homeobox Genes in Neural Cell Differentiation. In: Juurlink, B.H.J., Krone, P.H., Kulyk, W.M., Verge, V.M.K., Doucette, J.R. (eds) Neural Cell Specification. Altschul Symposia Series, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1929-4_5

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  • DOI: https://doi.org/10.1007/978-1-4615-1929-4_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5790-2

  • Online ISBN: 978-1-4615-1929-4

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