Abstract
The majority of transplanted neural cells fail to survive for more than a few days or weeks, and in many transplants, 90 to 98% of transplanted cells undergo cell death within this time period. Therefore, the study of the mechanisms controlling neural cell death is of relevance to the optimization of neural transplants. The predominant mode of neural cell death following trophic factor withdrawal is apoptosis. Gene products controlling neural apoptosis in both a positive and negative way have been discovered and characterized. Some of these gene products also control non-apoptotic cell death; therefore, an investigation of the role(s) of pro-apoptotic genes in limiting transplant survival is warranted. In addition, an evaluation of the effects of expressing anti-apoptotic genes in limiting transplant survival is also warranted. An evaluation of the effects of expressing anti-apoptotic genes in neural transplants is, thus, appropriate, and preliminary results in this area have been obtained.
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Bredesen, D.E. (1995). Modulation of Cell Death in Neural Cell Lines and Transplants. In: Juurlink, B.H.J., Krone, P.H., Kulyk, W.M., Verge, V.M.K., Doucette, J.R. (eds) Neural Cell Specification. Altschul Symposia Series, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1929-4_24
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DOI: https://doi.org/10.1007/978-1-4615-1929-4_24
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