Abstract
Neurofilaments (NFs) are formed by the copolymerization of three proteins, the light (NF-L), medium (NF-M) and heavy (NF-H) subunits (Hoffman and Lasek,1975; Liem et al., 1978). The three NF subunits are encoded by different genes and several reports have shown that the genes are under separate developmental control (Shaw and Weber, 1982; Carden et al., 1987; Cochard and Paulin, 1984; Julien et al., 1986). Direct evidence for a role of neurofilaments in the control of axonal calibers was recently provided from the recent analyses of a mutant quail (Ohara et al. 1993) and of a transgenic mouse (Eyer and Peterson 1994) with NF-deficient axons.
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Julien, JP., Côté, F., Charron, G., Collard, JF. (1995). Neurodegeneration Induced by De-Regulation of Neurofilament Gene Expression in Transgenic Mice. In: Juurlink, B.H.J., Krone, P.H., Kulyk, W.M., Verge, V.M.K., Doucette, J.R. (eds) Neural Cell Specification. Altschul Symposia Series, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1929-4_17
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