Rearrangement of the ALL1 Gene in Acute Myeloid Leukemia without Chromosomal Translocations

  • Steven A. Schichman
  • Carlo M. Croce
Part of the Pezcoller Foundation Symposia book series (PFSO, volume 6)


When the chromosomes of human leukemia cells are viewed through the microscope, aberrations are frequently seen in chromosome structure and number. These abnormalities comprise the gain, loss, or rearrangement of whole chromosomes or chromosome segments. More than 20 years ago, researchers discovered that certain types of chromosomal abnormalities were consistently associated with certain types of leukemia. These observations led to the hypothesis, now shown to be correct, that some types of chromosomal defects are causally related to the formation of leukemia.1


Acute Myeloid Leukemia Acute Lymphoblastic Leukemia Acute Leukemia Chromosomal Translocation Tandem Duplication 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Steven A. Schichman
    • 1
  • Carlo M. Croce
    • 1
  1. 1.Jefferson Cancer Institute Jefferson Cancer Center and Department of Microbiology and ImmunologyJefferson Medical College of Thomas Jefferson UniversityPhiladelphiaUSA

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