Structure and Expression Pattern of the PML Gene

  • Marta Fagioli
  • Pier Giuseppe Pelicci
Part of the Pezcoller Foundation Symposia book series (PFSO, volume 6)

Abstract

APL is characterized by a reciprocal translocation that involves chromosomes 15 and 17. As a consequence of this translocation two recombinant chromosomes are formed: 15q+ and 17q- . Expression of the t(15;17) is strictly limited to neoplastic promyelocytes and is often (70–90%) the only chromosomal anomaly seen in the neoplastic metaphases. Since the t(15;17) is associated exclusively with a promyelocytic phenotype and there are no other known chromosome alterations able to express this phenotype, it is suggested that the t(15;17) is implicated in the pathogenesis of APL (1–2).

Keywords

Zinc Lymphoma Codon Leukemia Recombination 

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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Marta Fagioli
    • 1
  • Pier Giuseppe Pelicci
    • 1
    • 2
  1. 1.Istituto di Medicina Interna e Scienze Oncologiche Policlinico MontelucePerugia UniversityPerugiaItaly
  2. 2.Istituto Clinica Medica IPoliclinico MontelucePerugiaItaly

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