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Structure and Expression Pattern of the PML Gene

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Normal and Malignant Hematopoiesis

Part of the book series: Pezcoller Foundation Symposia ((PFSO,volume 6))

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Abstract

APL is characterized by a reciprocal translocation that involves chromosomes 15 and 17. As a consequence of this translocation two recombinant chromosomes are formed: 15q+ and 17q- . Expression of the t(15;17) is strictly limited to neoplastic promyelocytes and is often (70–90%) the only chromosomal anomaly seen in the neoplastic metaphases. Since the t(15;17) is associated exclusively with a promyelocytic phenotype and there are no other known chromosome alterations able to express this phenotype, it is suggested that the t(15;17) is implicated in the pathogenesis of APL (1–2).

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Authors and Affiliations

  1. Istituto di Medicina Interna e Scienze Oncologiche Policlinico Monteluce, Perugia University, Perugia, Italy

    Marta Fagioli & Pier Giuseppe Pelicci

  2. Istituto Clinica Medica I, Policlinico Monteluce, 06100, Perugia, Italy

    Pier Giuseppe Pelicci

Authors
  1. Marta Fagioli
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  2. Pier Giuseppe Pelicci
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Editors and Affiliations

  1. Roswell Park Cancer Institute, Buffalo, New York, USA

    Enrico Mihich

  2. The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia

    Donald Metcalf

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Fagioli, M., Pelicci, P.G. (1995). Structure and Expression Pattern of the PML Gene. In: Mihich, E., Metcalf, D. (eds) Normal and Malignant Hematopoiesis. Pezcoller Foundation Symposia, vol 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1927-0_13

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  • DOI: https://doi.org/10.1007/978-1-4615-1927-0_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5789-6

  • Online ISBN: 978-1-4615-1927-0

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