Melatonin and the Vertebrate Circadian System: Pharmacological Effects
The effects of melatonin on the vertebrate circadian system can be studied with two questions in mind: first, to elucidate the physiological role of endogenous melatonin as a chemical messenger relaying information between postulated components of the circadian system (the retina, suprachiasmatic nuclei (SCN) and pineal gland (Gwinner, 1978; Menaker, 1982), and secondly, to investigate the effects on this system of administering melatonin at pharmacological dose levels.
KeywordsCircadian Rhythm Activity Rhythm Circadian System Phase Response Curve Pineal Organ
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