Abstract
The effects of melatonin on the vertebrate circadian system can be studied with two questions in mind: first, to elucidate the physiological role of endogenous melatonin as a chemical messenger relaying information between postulated components of the circadian system (the retina, suprachiasmatic nuclei (SCN) and pineal gland (Gwinner, 1978; Menaker, 1982), and secondly, to investigate the effects on this system of administering melatonin at pharmacological dose levels.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Adler, K. and Taylor, D.H., 1980, Melatonin and thyroxine: Influence on compass orientation in salamanders, J. Comp. Physiol. 136:235.
Armstrong, S.M., and Chesworth, M.J., 1987, Melatonin phase-shifts a mammalian circadian clock, in: “Fundamentals and Clinics in Pineal Research”, G.P. Trentini, C. De Gaetani and P. Pévet, eds., Raven, New York.
Armstrong, S.M. and Redman, J., 1985, Melatonin administration: Effects on rodent circadian rhythms, in: “Photoperiodism, Melatonin and the Pineal”, D. Evered and S. Clark, eds., Ciba Foundation Symposium 117, Pitman, London.
Armstrong, S.M. and Redman, J.R., 1993, Melatonin and circadian rhythmicity, in: “Melatonin Biosynthesis, Physiological Effects and Clinical Applications”, H-S Yu and R.J. Reiter, eds., CRC Press, Boca Raton, Florida.
Armstrong, S.M., Thomas, E.M.V., and Chesworth, M.J., 1989, Melatonin induced phase-shifts of rat circadian rhythms, in: “Advances in Pineal Research”, R.J. Reiter and S.F. Pang, eds., Libbey and Co, U.K., 265.
Aschoff, J., 1960, Exogenous and endogenous components in circadian rhythms. Cold Spring Harbor Symp. Quant. Biol. 25: 11.
Beaven, M., 1991, The effect of melatonin on the circadian rhythms of locomotor activity and body temperature in the rat: the search for a non-SCN pacemaker, Unpublished Honours Thesis, Department of Psychology, Monash University.
Beldhius, H.J.A., Dittami, J.P., and Gwinner, E., 1988, Melatonin and the circadian rhythms of feeding and perch-hopping in the European starling, Sturnus vulgaris, J. Comp. Physiol. A, 164:7 .
Binkley, S. and Mosher, K., 1985, Oral melatonin produces arrhythmia in sparrows, Experientia 41:1615.
Cheung, P.W. and McCormack, C.E., 1982, Failure of pinealectomy or melatonin to alter circadian activity rhythm of the rat, Am. J. Physiol. 242:R261.
Darrow, J.M. and Goldman, B.D., 1986, Effects of pinealectomy and timed daily melatonin infusions on wheel-running rhythms in Djungarian hamsters, presented at Society for Neuroscience, November 9 to 14:843.
Ebihara, S. and Kawamura, H., 1981, The role of the pineal organ and the suprachiasmatic nucleus in the control of circadian locomotor rhythms in the Java sparrow, Padda aryzivoza, J. Comp. Physiol. 141:207.
Ebihara, S., Uchiyama, K. and Oshima, I., 1984, Circadian organization in the pidgeon, Columba livia: the role of the pineal organ and the eye, J. Comp. Physiol. 154:59.
Fuchs, J.L., 1983, Effects of pinealectomy and subsequent melatonin implants on activity rhythms in the house-finch (Carpodacus mexicanus), J. Comp. Physiol. 153:413.
Gwinner, E., 1978, Effects of pinealectomy on circadian locomotor activity rhythms in European starlings, Sturnus vulgaris, J. Comp. Physiol. 126:123
Gwinner, E. and Benzinger, I., 1978, Synchronization of a circadian rhythm in pinealectomized European starlings by daily injections of melatonin, J. Comp. Physiol. 127:209.
Gwinner, E., Subbaraj, R., Bluhm, C.K., and Gerkema, M., 1987, Differential effects of pinealectomy on circadian rhythms of feeding and perch hopping in the European starling, J. Biol. Rhythms 2(2): 109.
Hastings, M.H., Mead, S.M., Vindlacheruvu, R.R., Ebling, F.J.P., Maywood, E.S. and Grosse,J., 1992, Non-photic phase shifting of the circadian activity rhythm of Syrian hampsters: the relative potency of arousal and melatonin, Brain Res. 591:20.
Hutchison, V.H., Black, J.J. and Erskine, D., 1979, Melatonin and chlorpromazine: Thermal selection in the mudpuppy, Necturus maculosus, Life Sci. 25:527.
Illnerová, H., Trentini, G.P., and Maslova, L., 1989, Melatonin accelerates reentrainment of the circadian rhythm of its own production, J. Comp. Physiol. 166:97.
Janik, D.S. and Menaker, M., 1990, Circadian locomotor rhythms in the desert iguana, I. The role of the eyes and the pineal, J. Comp. Physiol. A 166:803.
Janik, D.S., Pickard, G.E. and Menaker, M., 1990, Circadian locomotor rhythms in the desert iguana II. Effects of electrolytic lesions to the hypothalamus, J. Comp. Physiol. A 166:811.
Joss, J.M.P., 1980, Autoradiographic localisation of sites of uptake of [H3] melatonin in the brain of a lizard and lamprey, in: “Pineal Function”, CD. Matthews and R.F. Seamark, eds., Elservier, Amsterdam.
Kirsch R., Belgnaoui, S. Gourmelen, S. and Pévet, P., 1993, Daily melatonin infusion entrains free-running activity in Syrian and Siberian hamsters, in: “Light and Biological Rhythms in Man”, L.Wetterberg, ed.,Pergamon Press, Oxford.
Lewy, A.J., Ahmed, S., Latham Jackson J.M., Sack,R.L., 1992, Melatonin shifts human circadian rhythms according to a phase-response curve, Chronobiol. Int. 9(5):380.
Menaker, M., 1982 The search for principles of physiological organization in vertebrate circadian systems, in: “Vertebrate Circadian Systems Structure and Physiology”, J. Aschoff, S. Daan and G. Gross, eds., Springer-Verlag, Berlin.
Mrosovsky, N., 1988, Phase response curves for social entrainment, J. Comp. Physiol. 162:35.
Puchalski, W., and Lynch, A., 1988, Daily melatonin injections affect the expression of circadian rhythmicity in Djungarian hamsters kept under a long-day photoperiod, Neuroendocr. 48:280.
Redman, J., Armstrong, S.M., and Ng, K.T., 1983, Free-running activity rhythms in the rat: Entrainment by melatonin, Science 219:1089.
Redman, J., and Roberts, C.M., 1991, Entrainment of rat activity rhythms by melatonin does not depend on wheel-running activity, Soc. Neurosci. Abstracts 17:673.
Simpson, S.M. and Follett, B.K., 1981, Pineal and hypothalamic pacemakers: their role in regulating circadian rhythmicity in Japanese quail, J. Comp. Physiol. 144:381
Thomas, E.M.V., and Armstrong, S.M., 1988, Melatonin administration entrains female rat activity rhythms in constant darkness but not in constant light, Am. J. Physiol. 255:R237,
Turek, F.W., McMillan, M.P. and Menaker, M., 1976, Melatonin: effects on the circadian locomotor rhythm of sparrows, Science 194:1441.
Vaněček, J., Pavlik, A., Illnerová, H., 1987, Hypothalamic melatonin receptor sites revealed by autoradiography, Brain Res. 435:359.
Underwood, H., 1977, Circadian organization in lizards: The rate of the pineal organ, Science 195:587.
Underwood, H., 1979, Melatonin affects circadian rhythmicity in lizards, J. Comp. Physiol. 130:317.
Underwood, H., 1981, Circadian organization in the lizard, Scelporus occidentalis: The effect of pinealectomy, blinding, and melatonin, J. Comp. Physiol. 141:537.
Underwood, H., 1986, Circadian rhythms in lizards: Phase response curve for melatonin, J. Pineal Res. 3:18.
Underwood, H., 1989, The pineal and melatonin: regulators of circadian function in lower vertebrates, Experientia 45(10):914.
Underwood, H. and Harless, M., 1985, Entrainment of the circadian rhythm of a lizard to melatonin injections, Physiol Behav. 35:267.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1995 Springer Science+Business Media New York
About this chapter
Cite this chapter
Redman, J.R. (1995). Melatonin and the Vertebrate Circadian System: Pharmacological Effects. In: Fraschini, F., Reiter, R.J., Stankov, B. (eds) The Pineal Gland and Its Hormones. NATO ASI Series, vol 277. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1911-9_10
Download citation
DOI: https://doi.org/10.1007/978-1-4615-1911-9_10
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-5781-0
Online ISBN: 978-1-4615-1911-9
eBook Packages: Springer Book Archive